Synthesis and radiolabelling of re(co)(3)-beta-elemene derivatives as potential therapeutic radiopharmaceuticals
文献类型：期刊论文
| 作者 | Ren, Yunfeng1,2; Sun, Yanhong1; Cheng, Kangmin1,2; Liu, Guifeng1,2; Shen, Yumei1 |
| 刊名 | Journal of labelled compounds & radiopharmaceuticals
 |
| 出版日期 | 2009-05-15 |
| 卷号 | 52期号:5-6页码:139-145 |
| 关键词 | Beta-elemene Tricarbonyl rhenium Re-188 Antiproliferative activity Ic50 |
| ISSN号 | 0362-4803 |
| DOI | 10.1002/jlcr.1580 |
| 通讯作者 | Shen, yumei(shenyumei@sinop.ac.cn) |
| 英文摘要 | Beta-elemene, (1s, 2s, 4r)-(-)-(1-methy-1-vinyl-2,4-diisopropenyl cyclohexane) is an anticancer agent from the traditional chinese herb medicinal. three novel re(co)(3)-beta-elemene derivatives including their radioactive conjugates containing n,n,n tridentate ligands and tricarbonyl rhenium (complex 12, 13, 14) were synthesized. their structures were characterized by infrared (ir), h-1-nmr and hrms. good radioactive yield (above 90%) and radioactive chemical purity with re-188 (above 95%) were obtained for all of the three derivatives (complex 15, 16, 17). the anti proliferative activity of non-radioactive beta-elemene-re(co)(3) derivatives on lewis lung cancer cells and hela cell lines were evaluated by wst-1 methods. the result shows substantial decrease in ic50 values compared with the parent compound beta-elemene. the synthesis and radiosynthesis of beta-elemene tricarbonyl rhenium conjugates provide the possibility to find a new kind of potential radiopharmaceuticals on beta-elemene. |
| WOS关键词 | BIOLOGICALLY-ACTIVE MOLECULES ; BETA-ELEMENE ; TAILOR-MADE ; CELL-CYCLE ; TC-99M ; ARREST ; LIGAND ; AGENTS ; CORE ; ACID |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| WOS类目 | Biochemical Research Methods ; Chemistry, Medicinal ; Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000267243600001 |
| 出版者 | WILEY-BLACKWELL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2404200 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shen, Yumei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Res Ctr Radiopharmaceut, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Yunfeng,Sun, Yanhong,Cheng, Kangmin,et al. Synthesis and radiolabelling of re(co)(3)-beta-elemene derivatives as potential therapeutic radiopharmaceuticals[J]. Journal of labelled compounds & radiopharmaceuticals,2009,52(5-6):139-145. |
| APA | Ren, Yunfeng,Sun, Yanhong,Cheng, Kangmin,Liu, Guifeng,&Shen, Yumei.(2009).Synthesis and radiolabelling of re(co)(3)-beta-elemene derivatives as potential therapeutic radiopharmaceuticals.Journal of labelled compounds & radiopharmaceuticals,52(5-6),139-145. |
| MLA | Ren, Yunfeng,et al."Synthesis and radiolabelling of re(co)(3)-beta-elemene derivatives as potential therapeutic radiopharmaceuticals".Journal of labelled compounds & radiopharmaceuticals 52.5-6(2009):139-145. |
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来源：中国科学院大学
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