中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Ephrina5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor

文献类型:期刊论文

作者Li, J-J2; Liu, D-P; Liu, G-T3; Xie, D.1
刊名Oncogene
出版日期2009-04-16
卷号28期号:15页码:1759-1768
关键词Ephrina5 Egfr C-cbl Glioma
ISSN号0950-9232
DOI10.1038/onc.2009.15
通讯作者Xie, d.(dxie@sibs.ac.cn)
英文摘要Eph receptors, the largest subfamily of receptor tyrosine kinases, and their ephrin ligands play important roles in nervous system development. recently, they have been implicated in tumorigenesis of different cancers. in this study, we showed that the expression of ephrina5 was dramatically downregulated in primary gliomas compared with normal tissues. forced expression of ephrina5 reduced tumorigenicity of human glioma u373 cells. epidermal growth factor receptor (egfr), which frequently acts as an oncoprotein in glioma, was greatly decreased in ephrina5-transfected glioma cells, and the two molecules exhibited a mutually exclusive expression pattern in primary glioma samples. we found that ephrina5 enhanced c-cbl binding to egfr, thus promoted ubiquitylation and degradation of the receptor. either ephrina5-fc or epha2-fc treatment simulating bidirectional signaling of eph/ephrin system resulted in egfr decrease. this study discovered that ephrina5 acted as a tumor suppressor in glioma, and its negative regulation of egfr contributed to the suppressive effects. in addition to identifying a novel mechanism underlying tumor suppressor activity of ephrina5, we also showed cross-talk between different receptor tyrosine kinase families in glioma. these.ndings may improve therapeutic strategies for glioma.
WOS关键词C-CBL ; EPH RECEPTORS ; TYROSINE KINASES ; GENE-EXPRESSION ; CANCER CELLS ; T-CELLS ; PHOSPHORYLATION ; BINDING ; LIGAND ; TUMORIGENICITY
WOS研究方向Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
WOS类目Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
语种英语
WOS记录号WOS:000265640400003
出版者NATURE PUBLISHING GROUP
URI标识http://www.irgrid.ac.cn/handle/1471x/2404260
专题中国科学院大学
通讯作者Xie, D.
作者单位1.Chinese Acad Sci, Mol Oncol Lab, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
2.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China
3.Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
推荐引用方式
GB/T 7714
Li, J-J,Liu, D-P,Liu, G-T,et al. Ephrina5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor[J]. Oncogene,2009,28(15):1759-1768.
APA Li, J-J,Liu, D-P,Liu, G-T,&Xie, D..(2009).Ephrina5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor.Oncogene,28(15),1759-1768.
MLA Li, J-J,et al."Ephrina5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor".Oncogene 28.15(2009):1759-1768.

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来源:中国科学院大学

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