Characterization of h5n1 influenza a viruses isolated from domestic green-winged teal
文献类型：期刊论文
| 作者 | Chen, Jianjun1,2; Yang, Zhongdong3; Chen, Quanjiao1; Liu, Xueying3; Fang, Fang4; Chang, Haiyan4; Li, Dongmei3; Chen, Ze1,3,4 |
| 刊名 | Virus genes
 |
| 出版日期 | 2009-02-01 |
| 卷号 | 38期号:1页码:66-73 |
| 关键词 | Domestic green-winged teal H5n1 Reassortment Hemagglutinin |
| ISSN号 | 0920-8569 |
| DOI | 10.1007/s11262-008-0289-y |
| 通讯作者 | Chen, ze(chenze2005@263.net) |
| 英文摘要 | Two avian influenza virus strains, a/domestic green-winged teal/hunan/67/2005 (h5n1) (d-gwt/67) and a/domestic green-winged teal/hunan/79/2005 (h5n1) (d-gwt/79), were isolated from healthy domestic green-winged teals (anas crecca) in hunan province, south china. genomic analysis showed that both isolates were reassortants. the hemagglutinin (ha) genes of the two isolates were closely related to that of an h5n1 strain isolated from tree sparrow (a/tree sparrow/henan/1/04). the neuraminidase (na) genes and the internal protein genes of both isolates were closely related to those from a/chicken/shantou/4231/2003-like (h5n1) viruses, with exception of the matrix (m) gene of d-gwt/79, which was closely related to that of the h7n3 strain a/mallard/netherlands/12/2000 isolated from wild mallard duck. the virulence of the two isolates was examined in chickens, ducks, and mice. both strains were found to be highly pathogenic in chickens and ducks, but showed low pathogenicity in mice. these findings contribute to the realization that domestic green-winged teals carrying the h5n1 virus may play an important role in transmitting the virus among birds. |
| WOS关键词 | HOST-RANGE RESTRICTION ; HONG-KONG ; MOLECULAR-BASIS ; GENE ; HEMAGGLUTININ ; PATHOGENICITY ; PATHOGENESIS ; INFECTION ; RESPONSES ; OUTBREAKS |
| WOS研究方向 | Genetics & Heredity ; Virology |
| WOS类目 | Genetics & Heredity ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000262409100008 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2404279 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Ze |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Shanghai Inst Biol Prod, Shanghai 200052, Peoples R China 4.Hunan Normal Univ, Coll Life Sci, Changsha 410081, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jianjun,Yang, Zhongdong,Chen, Quanjiao,et al. Characterization of h5n1 influenza a viruses isolated from domestic green-winged teal[J]. Virus genes,2009,38(1):66-73. |
| APA | Chen, Jianjun.,Yang, Zhongdong.,Chen, Quanjiao.,Liu, Xueying.,Fang, Fang.,...&Chen, Ze.(2009).Characterization of h5n1 influenza a viruses isolated from domestic green-winged teal.Virus genes,38(1),66-73. |
| MLA | Chen, Jianjun,et al."Characterization of h5n1 influenza a viruses isolated from domestic green-winged teal".Virus genes 38.1(2009):66-73. |
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来源：中国科学院大学
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