Whole genome sequencing of lamb rotavirus and comparative analysis with other mammalian rotaviruses
文献类型：期刊论文
| 作者 | Chen, Yanjun1,2; Zhu, Weiwen3; Sui, Shuo1; Yin, Yuxin1; Hu, Songnian1; Zhang, Xiaowei1 |
| 刊名 | Virus genes
 |
| 出版日期 | 2009-04-01 |
| 卷号 | 38期号:2页码:302-310 |
| 关键词 | Rotavirus Genome Genotyping Phylogenetic analysis Comparative analysis |
| ISSN号 | 0920-8569 |
| DOI | 10.1007/s11262-009-0332-7 |
| 通讯作者 | Hu, songnian(husn@big.ac.cn) |
| 英文摘要 | Rotavirus (rv) epidemiological surveys with molecular analysis of various strains are required for gastroenteritis control and prevention. the lamb rotavirus strain nt, isolated from a diarrhea lamb in china, is considered as a promising vaccine strain. the whole genome of the lamb-nt strain was determined by sequence analysis. sequence identity and phylogenetic analysis defined the lamb-nt strain as group a, genotype g10p[15]/nsp4[a]/sg1 strain. comparative genomic analysis of the lamb-nt strain and 17 reference strains reveals that gene reassortments between rotaviruses circulating in different species occurred. alignment of protein sequences of the genes shows some variations in the important functional regions of vp3 and vp4. these variations are related to host range restriction, virulence, and other potential characters of rotaviruses. besides, this study also makes a significant foundation for the study of genetic classification, epidemiology, and antigenic diversity of rotaviruses on the molecular level. |
| WOS关键词 | GROUP-A ROTAVIRUS ; COMPLETE NUCLEOTIDE-SEQUENCE ; AMINO-ACID-SEQUENCE ; GUANYLYLTRANSFERASE ACTIVITY ; MOLECULAR CHARACTERIZATION ; MIXED INFECTIONS ; VACCINE ; CHILDREN ; EFFICACY ; INFANTS |
| WOS研究方向 | Genetics & Heredity ; Virology |
| WOS类目 | Genetics & Heredity ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000263900500015 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2404591 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Hu, Songnian |
| 作者单位 | 1.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genom Sci & Informat, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Beijing Natcare Biotech Co L, Beijing 10008, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yanjun,Zhu, Weiwen,Sui, Shuo,et al. Whole genome sequencing of lamb rotavirus and comparative analysis with other mammalian rotaviruses[J]. Virus genes,2009,38(2):302-310. |
| APA | Chen, Yanjun,Zhu, Weiwen,Sui, Shuo,Yin, Yuxin,Hu, Songnian,&Zhang, Xiaowei.(2009).Whole genome sequencing of lamb rotavirus and comparative analysis with other mammalian rotaviruses.Virus genes,38(2),302-310. |
| MLA | Chen, Yanjun,et al."Whole genome sequencing of lamb rotavirus and comparative analysis with other mammalian rotaviruses".Virus genes 38.2(2009):302-310. |
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来源：中国科学院大学
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