Potential protection of curcumin against amyloid beta-induced toxicity on cultured rat prefrontal cortical neurons
文献类型：期刊论文
| 作者 | Qin, Xiao-Yan3,4; Cheng, Yong1,2; Cui, Jia1,2; Zhang, Yan1,2; Yu, Long-Chuan1,2 |
| 刊名 | Neuroscience letters
 |
| 出版日期 | 2009-10-02 |
| 卷号 | 463期号:2页码:158-161 |
| 关键词 | Amyloid beta (a beta) Curcumin Prefrontal cortical neuron Bcl(2) Caspase-3 |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2009.07.047 |
| 通讯作者 | Yu, long-chuan(yulc@pku.edu.cn) |
| 英文摘要 | The present study explored the effect of curcumin against amyloid beta (a beta)-induced toxicity on cultured rat primary prefrontal cortical neurons. the results showed that administration of 10 mu m of curcumin induced significantly protection against 20 mu m of a beta(25-35)-induced toxicity on the cultured rat primary prefrontal cortical neurons tested by mtt and tunel assays. we further examined the involvements of the apoptotic or anti-apoptotic proteins in curcumin protection against a beta(25-35)-induced cytotoxicity on cultured neurons and found that the content of apoptotic protein caspase-3 was increased and the content of anti-apoptotic factor bcl(2) was decreased significantly after a beta(25-35) treatments, while administration of curcumin significantly inhibited the a beta(25-35)-induced increases in the content of caspase-3 and inhibited the a025-35-induced decreases in the content of bcl2 tested by western blot. the results suggest that curcumin protects cultured rat primary prefrontal cortical neurons against a beta-induced cytotoxicity, and both bcl2 and caspase-3 are involved in the curcumin-induced protective effects. (c) 2009 elsevier ireland ltd. all rights reserved. |
| WOS关键词 | BAX PROTEIN EXPRESSION ; ALZHEIMERS-DISEASE ; APOPTOSIS ; BCL-2 |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000269808700012 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2404854 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu, Long-Chuan |
| 作者单位 | 1.Peking Univ, Neurobiol Lab, Beijing 100871, Peoples R China 2.Peking Univ, State Key Lab Biomembrane & Membrane Biotechnol, Coll Life Sci, Beijing 100871, Peoples R China 3.Minzu Univ China, Biotechnol Lab, Beijing 100081, Peoples R China 4.Minzu Univ China, State Key Lab Chinese Ethn Minor Tradit Med, Beijing 100081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Xiao-Yan,Cheng, Yong,Cui, Jia,et al. Potential protection of curcumin against amyloid beta-induced toxicity on cultured rat prefrontal cortical neurons[J]. Neuroscience letters,2009,463(2):158-161. |
| APA | Qin, Xiao-Yan,Cheng, Yong,Cui, Jia,Zhang, Yan,&Yu, Long-Chuan.(2009).Potential protection of curcumin against amyloid beta-induced toxicity on cultured rat prefrontal cortical neurons.Neuroscience letters,463(2),158-161. |
| MLA | Qin, Xiao-Yan,et al."Potential protection of curcumin against amyloid beta-induced toxicity on cultured rat prefrontal cortical neurons".Neuroscience letters 463.2(2009):158-161. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。