The involvement of sortase a in high virulence of stss-causing streptococcus suis serotype 2
文献类型：期刊论文
| 作者 | Wang, Changjun1,2; Li, Ming2,3; Feng, Youjun4,5; Zheng, Feng2; Dong, Yaqing2; Pan, Xiuzhen2; Cheng, Gong2; Dong, Ruiping2; Hu, Dan2; Feng, Xiaodan2 |
| 刊名 | Archives of microbiology
 |
| 出版日期 | 2009 |
| 卷号 | 191期号:1页码:23-33 |
| 关键词 | Streptococcus suis serotype 2 Sortase a Lpxtg motif Pathogenicity |
| ISSN号 | 0302-8933 |
| DOI | 10.1007/s00203-008-0425-z |
| 通讯作者 | Tang, jiaqi(tjq85@hotmail.com) |
| 英文摘要 | Sortase a (srta), originally identified as a transpeptidase in staphylococcus aureus, plays key roles in full virulence of pathogenic bacteria. in silico genome-wide search suggested a srta homologue from 05zyh33, a chinese human isolate of streptococcal toxic shock syndrome (stss)-causing streptococcus suis serotype 2 (s. suis 2, ss2). an isogenic srta mutant (delta srta) of 05zyh33 strain was obtained by homologous recombination. immunofluorescence analysis revealed that two known virulence-associated surface proteins featuring leu-pro-x-thr-gly motif, muramidase-released protein and surface antigen one, were absent in the delta srta. piglet infection experiments showed that deletion of srta attenuated the full virulence of 05zyh33 strain, and impaired its colonizing potential in specific organs. furthermore, the delta srta displayed significant reduction in adherence to human cells (hep-2 and human umbilical vein endothelial cells). collectively, we concluded that srta was involved in the virulence manifestation of stss-causing ss2. |
| WOS关键词 | GRAM-POSITIVE BACTERIA ; STAPHYLOCOCCUS-AUREUS SORTASE ; FIBRONECTIN-BINDING PROTEIN ; GROUP-A STREPTOCOCCUS ; SURFACE-PROTEINS ; CELL-WALL ; CORYNEBACTERIUM-DIPHTHERIAE ; SRTA GENE ; NUCLEOTIDE-SEQUENCE ; RELEASED PROTEIN |
| WOS研究方向 | Microbiology |
| WOS类目 | Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000261618500003 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2404868 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tang, Jiaqi |
| 作者单位 | 1.Nanjing Med Univ, Jiangsu Prov Key Lab Modern Pathogen Biol, Nanjing, Peoples R China 2.Res Inst Med Nanjing Command, Dept Epidemiol, Nanjing, Peoples R China 3.Third Mil Med Univ, Dept Microbiol, Chongqing, Peoples R China 4.Chinese Acad Sci, Inst Microbiol, Ctr Mol Immunol, Beijing, Peoples R China 5.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Changjun,Li, Ming,Feng, Youjun,et al. The involvement of sortase a in high virulence of stss-causing streptococcus suis serotype 2[J]. Archives of microbiology,2009,191(1):23-33. |
| APA | Wang, Changjun.,Li, Ming.,Feng, Youjun.,Zheng, Feng.,Dong, Yaqing.,...&Tang, Jiaqi.(2009).The involvement of sortase a in high virulence of stss-causing streptococcus suis serotype 2.Archives of microbiology,191(1),23-33. |
| MLA | Wang, Changjun,et al."The involvement of sortase a in high virulence of stss-causing streptococcus suis serotype 2".Archives of microbiology 191.1(2009):23-33. |
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来源：中国科学院大学
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