Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells
文献类型：期刊论文
| 作者 | Liu, Zhen1,2; Liu, Yang1,2; Wang, Huiqiang1,2; Ge, Xinjian1,2; Jan, Qihuang1,2; Ding, Guanghui3; Hu, Yanan1,2; Zhou, Ben1,2; Chen, Zhongjian1,2; Ge, Xuemei1,2 |
| 刊名 | International journal of biochemistry & cell biology
 |
| 出版日期 | 2009-12-01 |
| 卷号 | 41期号:12页码:2528-2537 |
| 关键词 | Acetyltransferase Gnat family Liver Hepatocellular carcinoma Apoptosis |
| ISSN号 | 1357-2725 |
| DOI | 10.1016/j.biocel.2009.08.009 |
| 通讯作者 | Zhai, qiwei(qwzhai@sibs.ac.cn) |
| 英文摘要 | Protein acetylation is increasingly recognized as an important post-translational modification. although a lot of protein acetyltransferases have been identified, a few putative acetyltransferases are yet to be studied. in this study, we identified a novel protein acetyltransferase, patt1, which belongs to gnat family. patt1 exhibited histone acetyltransferase activity and auto-acetylation activity. deletion and mutation analysis of the predicted acetyltransferase domain in patt1 showed that the conserved glu139 was an important residue for its protein acetyltransferase activity. furthermore, we found that patt1 was highly expressed in liver and significantly downregulated in hepatocellular carcinoma tissues. in addition, we showed that overexpression of patt1 enhanced the apoptosis of hepatoma cells dependent on its acetyltransferase activity, whereas knockdown of patt1 significantly protected chang liver cells from apoptosis. these data suggest that patt1 might be involved in the development of hepatocellular carcinoma, and could be served as a potential therapy target for hepatocellular carcinoma. (c) 2009 elsevier ltd. all rights reserved. |
| WOS关键词 | ACUTE MYELOID-LEUKEMIA ; HISTONE ACETYLTRANSFERASES ; N-ACETYLTRANSFERASES ; CANCER-THERAPY ; DNA-BINDING ; ACETYLATION ; P300 ; MOZ ; PROLIFERATION ; DEACETYLASES |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000272218400025 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2404885 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhai, Qiwei |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China 3.Tongji Univ, Dept Hepatobiliary Surg, Shanghai Peoples Hosp 10, Sch Med, Shanghai 200072, Peoples R China 4.Second Mil Med Univ, Dept Hepatobiliary Surg, Eastern Hepatobiliary Surg Hosp, Shanghai 200438, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhen,Liu, Yang,Wang, Huiqiang,et al. Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells[J]. International journal of biochemistry & cell biology,2009,41(12):2528-2537. |
| APA | Liu, Zhen.,Liu, Yang.,Wang, Huiqiang.,Ge, Xinjian.,Jan, Qihuang.,...&Zhai, Qiwei.(2009).Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells.International journal of biochemistry & cell biology,41(12),2528-2537. |
| MLA | Liu, Zhen,et al."Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells".International journal of biochemistry & cell biology 41.12(2009):2528-2537. |
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来源：中国科学院大学
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