Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(v) dihydrate in streptozotocin-induced diabetic rats
文献类型：期刊论文
| 作者 | Li, Ming1; Smee, Jason J.2,3; Ding, Wenjun1; Crans, Debbie C.2 |
| 刊名 | Journal of inorganic biochemistry
 |
| 出版日期 | 2009-04-01 |
| 卷号 | 103期号:4页码:585-589 |
| 关键词 | Vanadium(v) Substituted dipicolinatooxovanadium(v) complex Anti-diabetic effects Streptozotocin-induced diabetic rats Blood glucose lowering Blood lipid lowering Structure activity relationships |
| ISSN号 | 0162-0134 |
| DOI | 10.1016/j.jinorgbio.2008.11.011 |
| 通讯作者 | Ding, wenjun(dingwj@gucas.ac.cn) |
| 英文摘要 | The evaluation of the anti-diabetic effects of an organic vanadium(v) complex in streptozotocin (m)induced diabetic rats was investigated. the stz-induced diabetic rats were orally administrated with sodium 4-amino-2,6-dipicolinatodioxovanadium(v) dihydrate (v5dipic-nh(2)), a vanadium(v) coordination compound. the compound was administered through drinking water at a concentration of 0.1 mg/ml for 20 days, and then the concentration was increased to 0.3 mg/ml for the following 20 days. at the end of the experiment, v5dipic-nh2 statistically significantly reduced the levels of blood glucose (p < 0.01), serum total cholesterol (p < 0.01), triglycerides (p < 0.01) and the activities of serum aspartate amino transferase (p < 0.05) and alkaline phosphatase (p < 0.01) compared to untreated diabetic animals. after treatment with 0.3 mg/ml. v5dipic-nh(2), the oral glucose tolerance was improved in diabetic animals (p<0.01). in addition, the daily intake of elemental vanadium was markedly decreased in v5dipic-nh(2)-treated diabetic rats compared to vanadyl sulfate (voso(4))-treated diabetic rats, which suggested that the anti-diabetic activity of the element vanadium was elevated after being modified with an organic ligand. these results suggested that v5dipic-nh(2), as an organic vanadium compound, is more effective than inorganic vanadium, salt at alleviating the symptoms of diabetes. (c) 2008 elsevier inc. all rights reserved. |
| WOS关键词 | PROTEIN-TYROSINE PHOSPHATASE-1B ; VANADIUM COMPOUNDS ; IN-VIVO ; AQUEOUS CHEMISTRY ; STATE PROPERTIES ; INSULIN ; COMPLEXES ; VANADATE ; GLUCOSE ; CHOLESTEROL |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear |
| 语种 | 英语 |
| WOS记录号 | WOS:000264904400015 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2405179 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ding, Wenjun |
| 作者单位 | 1.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China 2.Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA 3.Univ Texas Tyler, Dept Chem, Tyler, TX 75799 USA |
| 推荐引用方式 GB/T 7714 | Li, Ming,Smee, Jason J.,Ding, Wenjun,et al. Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(v) dihydrate in streptozotocin-induced diabetic rats[J]. Journal of inorganic biochemistry,2009,103(4):585-589. |
| APA | Li, Ming,Smee, Jason J.,Ding, Wenjun,&Crans, Debbie C..(2009).Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(v) dihydrate in streptozotocin-induced diabetic rats.Journal of inorganic biochemistry,103(4),585-589. |
| MLA | Li, Ming,et al."Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(v) dihydrate in streptozotocin-induced diabetic rats".Journal of inorganic biochemistry 103.4(2009):585-589. |
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来源：中国科学院大学
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