Synergistic anti-parkinsonism activity of high doses of b vitamins in a chronic cellular model
文献类型：期刊论文
| 作者 | Jia, Haiqun2,3; Liu, Zhongbo2,3; Li, Xin2; Feng, Zhihui2,3; Hao, Jiejie2,3; Li, Xuesen2,3; Shen, Weili2; Zhang, Hongyu2; Liu, Jiankang1,4 |
| 刊名 | Neurobiology of aging
 |
| 出版日期 | 2010-04-01 |
| 卷号 | 31期号:4页码:636-646 |
| 关键词 | Mitochondrial membrane potential Complex i Reactive oxygen species Oxidative dna damage Protein carbonyl |
| ISSN号 | 0197-4580 |
| DOI | 10.1016/j.neurobiolaging.2008.05.031 |
| 通讯作者 | Liu, jiankang() |
| 英文摘要 | We propose that elevation of mitochondrial enzyme cofactors may prevent or ameliorate neurodegenerative diseases by improving mitochondria! function in the present study, we investigated the effects of high doses of b vitamins, the precursors of mitochondrial enzyme cofactors, on mitochondrial dysfunction, oxidative stress, and parkinsonism in a 4-week long rotenone treatment-induced cellular model of parkinson's disease (pd) pretreatment with b vitamins (also 4 weeks) prevented rotenone-induced (1) mitochondrial dysfunction, including reduced mitochondrial membrane potential and activities of complex i; (2) oxidative stress, including increase in reactive oxygen species, oxidative dna damage and protein oxidation, and (3) parkinsonism parameters, including accumulation of alpha-synuclein and poly-ubiquitin the optimum doses were found around 2 5- and 5-fold of that in normal mem medium. the 4-week pretreatment was chosen based on time-dependent experiments that pretreatments longer than 2 weeks resulted in a decrease in oxidants, an increase in oxygen consumption, and up-regulation of complex i activity and pgc-1 alpha expression. individual b vitamins at the same doses did not show a similar effect suggesting that these b vitamins work synergistically these results suggest that administration of high doses of b vitamins sufficient to elevate mitochondrial enzyme cofactors may be effective in preventing pd by reducing oxidative stress and improving mitochondrial function. (c) 2008 elsevier inc all rights reserved |
| WOS关键词 | ALPHA-LIPOIC ACID ; MITOCHONDRIAL DECAY ; OXIDATIVE DAMAGE ; COENZYME Q(10) ; OLD RATS ; BINDING-AFFINITY ; DEFICIENT MICE ; COMET ASSAY ; DNA-DAMAGE ; COMPLEX-I |
| WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
| WOS类目 | Geriatrics & Gerontology ; Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000276759700011 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2405473 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Jiankang |
| 作者单位 | 1.Univ Calif Irvine, Inst Brain Aging & Dementia, Gillespie Neurosci Res Facil 1261, Irvine, CA 92697 USA 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 4.E China Normal Univ, Coll Phys Educ & Hlth, Inst Sports & Nutr, Shanghai 200241, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Haiqun,Liu, Zhongbo,Li, Xin,et al. Synergistic anti-parkinsonism activity of high doses of b vitamins in a chronic cellular model[J]. Neurobiology of aging,2010,31(4):636-646. |
| APA | Jia, Haiqun.,Liu, Zhongbo.,Li, Xin.,Feng, Zhihui.,Hao, Jiejie.,...&Liu, Jiankang.(2010).Synergistic anti-parkinsonism activity of high doses of b vitamins in a chronic cellular model.Neurobiology of aging,31(4),636-646. |
| MLA | Jia, Haiqun,et al."Synergistic anti-parkinsonism activity of high doses of b vitamins in a chronic cellular model".Neurobiology of aging 31.4(2010):636-646. |
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来源：中国科学院大学
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