Novel micrornas in silkworm (bombyx mori)
文献类型：期刊论文
| 作者 | Cai, Yimei1,2; Yu, Xiaomin1; Zhou, Qing1; Yu, Caixia1; Hu, Haiyan1,2; Liu, Jiucheng1,2; Lin, Hongbin1; Yang, Jin1; Zhang, Bing1; Cui, Peng1 |
| 刊名 | Functional & integrative genomics
 |
| 出版日期 | 2010-08-01 |
| 卷号 | 10期号:3页码:405-415 |
| 关键词 | Microrna Silkworm Solid High-throughput |
| ISSN号 | 1438-793X |
| DOI | 10.1007/s10142-010-0162-7 |
| 通讯作者 | Hu, songnian(husn@big.ac.cn) |
| 英文摘要 | We acquired more than 4 million useful sequences using a high-throughput method from a library for mirna identification, which is constructed from a mixture of 14 rna samples from different developmental stages. we mapped 247,410 reads to known silkworm mirnas in mirbase (13.0), 701,913 reads to other rna molecules based on sequence homology, and 3,219,395 reads to the silkworm genome. our analysis identified 54 silkworm known mirnas. a striking strand bias between mirnas and their corresponding mirna*s was found, and was speculated to reflect that transcripts from the passenger strand of pre-mirnas may have important biological roles. using an elaborate screening protocol, we predicted 287 candidate novel mirnas (represent 116,494 short reads), and 59 of them have both mirna and mirna* sequences. most of the previously identified silkworm mirnas are cross-species conserved with a high abundance, while those predicted candidates tend to be species-specific mirnas. our discovery of snps among mirnas implied within-species functional diversity. target prediction uncovers that considerable silkworm mirnas may aim at modulating more than one hormone signaling pathway components and/or hormone biosynthesis-related proteins implying their important roles in silkworm development. |
| WOS关键词 | DROSOPHILA-MELANOGASTER ; MICROPROCESSOR COMPLEX ; LET-7 MICRORNA ; MIRNA GENES ; EXPRESSION ; CANCER ; RNA ; BIOGENESIS ; INSECT ; MICROARRAYS |
| WOS研究方向 | Genetics & Heredity |
| WOS类目 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000280238200010 |
| 出版者 | SPRINGER HEIDELBERG |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2405604 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Hu, Songnian |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Genome Sci & Informat, Beijing Inst Genom, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, Yimei,Yu, Xiaomin,Zhou, Qing,et al. Novel micrornas in silkworm (bombyx mori)[J]. Functional & integrative genomics,2010,10(3):405-415. |
| APA | Cai, Yimei.,Yu, Xiaomin.,Zhou, Qing.,Yu, Caixia.,Hu, Haiyan.,...&Yu, Jun.(2010).Novel micrornas in silkworm (bombyx mori).Functional & integrative genomics,10(3),405-415. |
| MLA | Cai, Yimei,et al."Novel micrornas in silkworm (bombyx mori)".Functional & integrative genomics 10.3(2010):405-415. |
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来源：中国科学院大学
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