Serum and urinary metabonomic study of human osteosarcoma
文献类型：期刊论文
| 作者 | Zhang, Zhiyu2; Qiu, Yunping3; Hua, Yingqi4; Wang, Yihuang8; Chen, Tianlu5,6; Zhao, Aihua5,6; Chi, Yi5,6; Pan, Li5,6; Hu, Shuo4; Li, Jian4 |
| 刊名 | Journal of proteome research
 |
| 出版日期 | 2010-09-01 |
| 卷号 | 9期号:9页码:4861-4868 |
| 关键词 | Osteosarcoma Gas chromatography-mass spectrometry Serum Urine Metabolomics Metabonomics |
| ISSN号 | 1535-3893 |
| DOI | 10.1021/pr100480r |
| 通讯作者 | Cai, zhengdong(zhdcai@gmail.com) |
| 英文摘要 | Osteosarcoma (os) is the most common malignant bone tumor found in children. currently, researchers have focused on protein and gene levels, while the associated metabolic variations have been poorly understood. in this study, we used a gas chromatography mass spectrometry approach and profiled small-molecule metabolites in serum and urine of 24 os patients, 19 benign bone tumor patients, and 32 healthy controls, to determine whether there are significant alterations associated with carcinogenesis. the metabonomic results demonstrate clear intergroup separations between healthy control subjects and bone tumor patients in the orthogonal partial least-squares-discriminant analysis (opls-da) models. differential metabolites identified from the metabonomic analysis suggest a disrupted energy metabolism in os patients, as characterized by significantly downregulated tca cycle and glycolysis, down-regulated lipid metabolism, dysregulated sugar levels, and up-regulated amino acid metabolism. additionally, an increased activity of glutathione metabolism, and increased polyamine metabolism also contributed to a characteristic metabolic signature of os patients. |
| WOS关键词 | IDENTIFYING DIFFERENCES ; ACID METABOLISM ; CANCER ; BONE ; PROFILES ; RATS ; SAMPLES ; GC/MS ; GENE ; DIET |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemical Research Methods |
| 语种 | 英语 |
| WOS记录号 | WOS:000281443700049 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2405636 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Cai, Zhengdong |
| 作者单位 | 1.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Musculoskeletal Oncol Ctr, Shanghai 200072, Peoples R China 2.China Med Univ, Affiliated Hosp 4, Dept Orthoped, Shenyang 110032, Peoples R China 3.Univ N Carolina Greensboro, Dept Nutr, Kannapolis, NC 28081 USA 4.Second Mil Med Univ, Changhai Hosp, Dept Orthoped, Shanghai 200433, Peoples R China 5.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Sch Pharm, Shanghai 200240, Peoples R China 6.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Minist Educ, Key Lab Syst Biomed, Shanghai 200240, Peoples R China 7.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Hlth Sci,State Key Lab Med Genom, Shanghai 200240, Peoples R China 8.Shanghai Jiao Tong Univ, RuiJin Hosp, Shanghai Inst Hematol, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhiyu,Qiu, Yunping,Hua, Yingqi,et al. Serum and urinary metabonomic study of human osteosarcoma[J]. Journal of proteome research,2010,9(9):4861-4868. |
| APA | Zhang, Zhiyu.,Qiu, Yunping.,Hua, Yingqi.,Wang, Yihuang.,Chen, Tianlu.,...&Jia, Wei.(2010).Serum and urinary metabonomic study of human osteosarcoma.Journal of proteome research,9(9),4861-4868. |
| MLA | Zhang, Zhiyu,et al."Serum and urinary metabonomic study of human osteosarcoma".Journal of proteome research 9.9(2010):4861-4868. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。