Potential protection of curcumin against intracellular amyloid beta-induced toxicity in cultured rat prefrontal cortical neurons
文献类型：期刊论文
| 作者 | Qin, Xiao-Yan3,4; Cheng, Yong1,2; Yu, Long-Chuan1,2 |
| 刊名 | Neuroscience letters
 |
| 出版日期 | 2010-08-09 |
| 卷号 | 480期号:1页码:21-24 |
| 关键词 | Curcumin Intracellular a beta Prefrontal cortical neurons Caspase-3 Akt Neuronal protective effect |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2010.05.062 |
| 通讯作者 | Yu, long-chuan(yulc@pku.edu.cn) |
| 英文摘要 | Recently the neuronal toxicity of intracellular amyloid beta (ia beta) in alzheimer's disease is attracting more and more attention. the present study explored the effects of curcumin on the ia beta-induced toxicity in primary cultured rat prefrontal cortical neurons. the cell viability of primary cultured prefrontal cortical neurons decreased significantly after virus driven transfection of a beta from 1 day to 7 days. interestingly, administration of 1 mu m, 10 mu m or 20 mu m of curcumin significantly inhibited the ia beta-induced toxicity in primary cultured rat prefrontal cortical neurons tested by mtt and ldh release assays. we further studied the involvements of apoptotic or neuroprotective pathway proteins in curcumin protection against ia beta-induced cytotoxicity in primary cultured rat prefrontal cortical neurons. the results demonstrated that the contents of activated caspase-3 increased significantly by ia beta, while curcumin significantly inhibited the ia beta-induced increases of activated caspase-3 tested by western blot. and the contents of p-akt decreased significantly after ia beta treatment, while administration of curcumin significantly inhibited the ia beta-induced decreases in the contents of p-akt. the results suggest that curcumin may play a protective effect in primary cultured rat prefrontal cortical neurons against ia beta-induced cytotoxicity, and both akt and caspase-3 are involved in the curcumin-induced protective effects. (c) 2010 published by elsevier ireland ltd. |
| WOS关键词 | ALZHEIMERS-DISEASE ; TRANSGENIC MICE ; A-BETA ; APOPTOSIS ; PLAQUES ; PATHWAY |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000280471400006 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2405790 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu, Long-Chuan |
| 作者单位 | 1.Peking Univ, Neurobiol Lab, Beijing 100871, Peoples R China 2.Peking Univ, State Key Lab Biomembrane & Membrane Biotechnol, Coll Life Sci, Beijing 100871, Peoples R China 3.Minzu Univ China, Biotechnol Lab, Beijing 100081, Peoples R China 4.Minzu Univ China, State Key Lab Chinese Ethn Minor Tradit Med, Coll Life & Environm Sci, Beijing 100081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Xiao-Yan,Cheng, Yong,Yu, Long-Chuan. Potential protection of curcumin against intracellular amyloid beta-induced toxicity in cultured rat prefrontal cortical neurons[J]. Neuroscience letters,2010,480(1):21-24. |
| APA | Qin, Xiao-Yan,Cheng, Yong,&Yu, Long-Chuan.(2010).Potential protection of curcumin against intracellular amyloid beta-induced toxicity in cultured rat prefrontal cortical neurons.Neuroscience letters,480(1),21-24. |
| MLA | Qin, Xiao-Yan,et al."Potential protection of curcumin against intracellular amyloid beta-induced toxicity in cultured rat prefrontal cortical neurons".Neuroscience letters 480.1(2010):21-24. |
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来源：中国科学院大学
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