Sustained release of insulin through skin by intradermal microdelivery system
文献类型：期刊论文
| 作者 | Wu, Yan1,2; Gao, Yunhua1; Qin, Guangjiong1,2; Zhang, Suohui1,2; Qiu, Yuqin1; Li, Fang1; Xu, Bai1,3 |
| 刊名 | Biomedical microdevices
 |
| 出版日期 | 2010-08-01 |
| 卷号 | 12期号:4页码:665-671 |
| 关键词 | Intradermal Microneedles Insulin Percutaneous Sustained release |
| ISSN号 | 1387-2176 |
| DOI | 10.1007/s10544-010-9419-0 |
| 通讯作者 | Gao, yunhua(yhgao@mail.ipc.ac.cn) |
| 英文摘要 | An intradermal microdelivery system comprising a wafer having 150-mu m long microneedles and an applicator was used for controlled release of insulin. insulin was topically applied on microneedle-pretreated skin. in vitro percutaneous studies showed that the penetration amount of fitc-insulin following microneedle pretreatment was enhanced significantly and continued to increase for several hours after the removal of donor phase. in vivo studies on diabetic rats confirmed that the pharmacodynamic profile of percutaneously administrated regular insulin was smooth, with the duration of action comparable to that of subcutaneously injected biphasic insulin. the effects of insulin concentration, duration and area of microneedle treatment on blood glucose lowering were studied in vivo. the results indicated that the duration of microneedle treatment and insulin concentration were key influencing factors to optimize blood glucose control. the extent of blood glucose lowering was in proportion to the area of microneedle treatment. |
| WOS关键词 | TRANSDERMAL DRUG-DELIVERY ; MICROFABRICATED MICRONEEDLES ; GLYCEMIC CONTROL ; TRANSPORT ; PAIN |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics |
| WOS类目 | Engineering, Biomedical ; Nanoscience & Nanotechnology |
| 语种 | 英语 |
| WOS记录号 | WOS:000279500200011 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2405846 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Gao, Yunhua |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Suzhou Natong Bionanotechnol Co Ltd, Suzhou 215123, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yan,Gao, Yunhua,Qin, Guangjiong,et al. Sustained release of insulin through skin by intradermal microdelivery system[J]. Biomedical microdevices,2010,12(4):665-671. |
| APA | Wu, Yan.,Gao, Yunhua.,Qin, Guangjiong.,Zhang, Suohui.,Qiu, Yuqin.,...&Xu, Bai.(2010).Sustained release of insulin through skin by intradermal microdelivery system.Biomedical microdevices,12(4),665-671. |
| MLA | Wu, Yan,et al."Sustained release of insulin through skin by intradermal microdelivery system".Biomedical microdevices 12.4(2010):665-671. |
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来源：中国科学院大学
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