A dimeric structure of pd-l1: functional units or evolutionary relics?
文献类型：期刊论文
| 作者 | Chen, Yong1,2,4; Liu, Peipei1,2; Gao, Feng3; Cheng, Hao1,2; Qi, Jianxun1; Gao, George F.1,2,4,5 |
| 刊名 | Protein & cell
 |
| 出版日期 | 2010-02-01 |
| 卷号 | 1期号:2页码:153-160 |
| 关键词 | Pd-l1 Crystal structure Dimer Costimulatory molecules B7 family |
| ISSN号 | 1674-800X |
| DOI | 10.1007/s13238-010-0022-1 |
| 通讯作者 | Gao, george f.(gaof@im.ac.cn) |
| 英文摘要 | Pd-l1 is a member of the b7 protein family, most of whose members so far were identified as dimers in a solution and crystalline state, either complexed or uncomplexed with their ligand(s). the binding of pd-l1 with its receptor pd-1 (cd279) delivers an inhibitory signal regulating the t cell function. simultaneously with the garboczi group, we successfully solved another structure of human pd-l1 (hpd-l1). our protein crystallized in the space group of c222(1) with two hpd-l1 molecules per asymmetric unit. after comparison of reported b7 structures, we have found some intrinsic factors involved in the interaction of these two molecules. based on these results, we tend to believe this uncomplexed hpd-l1 structure demonstrated its potential dimeric state in solution, althougt it could just be an evolutionary relic, too weak to be detected under present technology, or still a functional unit deserved our attentions. |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000208510400008 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2406038 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Gao, George F. |
| 作者单位 | 1.Chinese Acad Sci CASPMI, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Microbiol, China Japan Joint Lab Mol Immunol & Mol Microbiol, Beijing 100101, Peoples R China 5.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yong,Liu, Peipei,Gao, Feng,et al. A dimeric structure of pd-l1: functional units or evolutionary relics?[J]. Protein & cell,2010,1(2):153-160. |
| APA | Chen, Yong,Liu, Peipei,Gao, Feng,Cheng, Hao,Qi, Jianxun,&Gao, George F..(2010).A dimeric structure of pd-l1: functional units or evolutionary relics?.Protein & cell,1(2),153-160. |
| MLA | Chen, Yong,et al."A dimeric structure of pd-l1: functional units or evolutionary relics?".Protein & cell 1.2(2010):153-160. |
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来源：中国科学院大学
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