The novel oct4 spliced variant oct4b1 can generate three protein isoforms by alternative splicing into oct4b
文献类型：期刊论文
| 作者 | Gao, Yuan1,2; Wang, Xia1; Han, Jin1; Xiao, Zhifeng1; Chen, Bing1; Su, Guannan1; Dai, Jianwu1 |
| 刊名 | Journal of genetics and genomics
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 37期号:7页码:461-465 |
| 关键词 | Oct4 Alternative splicing Alternative translation initiation Stress |
| ISSN号 | 1673-8527 |
| DOI | 10.1016/s1673-8527(09)60065-5 |
| 通讯作者 | Dai, jianwu(jwdai@genetics.ac.cn) |
| 英文摘要 | Oct4 is one of the key transcription factors in maintaining the pluripotency and self-renewal of embryonic stem (es) cells. human oct4 can generate two isoforms oct4a and oct4b by alternative splicing. oct4b1 is a recently discovered novel oct4 spliced variant, which has been considered as a putative marker of stemness. compared with the oct4b mrna, oct4b1 mrna is generated by retaining intron 2 as a cryptic exon which contains a tga stop codon in it. as a result, the protein product of oct4b1 mrna could be truncated. interestingly, we present here that oct4b1 can indirectly produce the same protein products as oct4b. we have demonstrated that oct4b1 mrna can be spliced into oct4b mrna, and encode three protein isoforms. the splicing of oct4b1 mrna into oct4b mrna can be remarkably inhibited by the mutation of the classical splicing site. our result suggests that oct4b mrna may originate from oct4b1 mrna by alternative splicing. |
| WOS关键词 | CONSERVED INTERNAL SIGNAL ; PRE-MESSENGER RNAS ; EXPRESSION ; CELLS ; INTRONS ; SITE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS类目 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000280313700007 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2406072 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianwu |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yuan,Wang, Xia,Han, Jin,et al. The novel oct4 spliced variant oct4b1 can generate three protein isoforms by alternative splicing into oct4b[J]. Journal of genetics and genomics,2010,37(7):461-465. |
| APA | Gao, Yuan.,Wang, Xia.,Han, Jin.,Xiao, Zhifeng.,Chen, Bing.,...&Dai, Jianwu.(2010).The novel oct4 spliced variant oct4b1 can generate three protein isoforms by alternative splicing into oct4b.Journal of genetics and genomics,37(7),461-465. |
| MLA | Gao, Yuan,et al."The novel oct4 spliced variant oct4b1 can generate three protein isoforms by alternative splicing into oct4b".Journal of genetics and genomics 37.7(2010):461-465. |
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来源：中国科学院大学
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