The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function
文献类型：期刊论文
| 作者 | Huang, Xinglu1,3; Teng, Xu2; Chen, Dong1; Tang, Fangqiong1; He, Junqi2 |
| 刊名 | Biomaterials
 |
| 出版日期 | 2010 |
| 卷号 | 31期号:3页码:438-448 |
| 关键词 | Mesoporous silica nanoparticles (msns) Shape Nonspecific cellular uptake Cell function Nanocarrier design |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2009.09.060 |
| 通讯作者 | Tang, fangqiong(tangfq@mail.ipc.ac.cn) |
| 英文摘要 | The interaction between nanoparticles (nps) and cells has been studied extensively, but the effect of particle shape on cell behavior has received little attention. herein three different shaped monodisperse mesoporous silica nanoparticles (msns) of similar particle diameter, chemical composition and surface charge but with different aspect ratios (ars, 1, 2, 4) were specially designed. then the effects of particle shape of these three different shaped particles on cellular uptake and behavior were studied. the results indicated that these different shaped particles were readily internalized in a375 human melanoma (a375) cells by nonspecific cellular uptake. particles with larger ars were taken up in larger amounts and had faster internalization rates. likewise, it was also found that particles with larger ars had a greater impact on different aspects of cellular function including cell proliferation, apoptosis, cytoskeleton formation, adhesion and migration. these results show that nanoparticles should no longer be viewed as simple carriers for biomedical applications, but can also play an active role in mediating biological effects. therefore, our findings may provide useful information for the development of new strategies for the design of efficient drug delivery nanocarriers and therapeutic systems and provide insights into nanotoxicity. (c) 2009 elsevier ltd. all rights reserved. |
| WOS关键词 | MESENCHYMAL STEM-CELLS ; DRUG-DELIVERY ; DENDRITIC CELLS ; IN-VIVO ; ADHESION ; FIBROBLASTS ; PARTICLES ; MIGRATION ; PATHWAYS ; DESIGN |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000272739200008 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2406115 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tang, Fangqiong |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Lab Controllable Preparat & Applicat Nanomat, Beijing 100190, Peoples R China 2.Capital Med Univ, Sch Basic Med Sci, Dept Biochem & Mol, Beijing 100069, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Xinglu,Teng, Xu,Chen, Dong,et al. The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function[J]. Biomaterials,2010,31(3):438-448. |
| APA | Huang, Xinglu,Teng, Xu,Chen, Dong,Tang, Fangqiong,&He, Junqi.(2010).The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function.Biomaterials,31(3),438-448. |
| MLA | Huang, Xinglu,et al."The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function".Biomaterials 31.3(2010):438-448. |
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来源：中国科学院大学
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