Rnf152, a novel lysosome localized e3 ligase with pro-apoptotic activities
文献类型：期刊论文
| 作者 | Zhang, Songling1,2; Wu, Wei1; Wu, Yanfang1; Zheng, Jiyan1; Suo, Talin1; Tang, Hong1; Tang, Jie1 |
| 刊名 | Protein & cell
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 1期号:7页码:656-663 |
| 关键词 | Rnf152 Ring finger Ubiquitinate Apoptosis |
| ISSN号 | 1674-800X |
| DOI | 10.1007/s13238-010-0083-1 |
| 通讯作者 | Tang, jie(jtang@sun5.ibp.ac.cn) |
| 英文摘要 | Ring finger protein 152 (rnf152) is a novel ring finger protein and has not been well characterized. we report here that rnf152 is a canonical ring finger protein and has e3 ligase activity. it is polyubiqitinated partly through lys-48-linked ubiquitin chains in vivo and this phenomenon is dependent on its ring finger domain and transmembrane domain. rnf152 is localized in lysosomes and co-localized with lamp3, a lysosome marker. moreover, over-expression of rnf152 in hela cells induces apoptosis. these results suggest that rnf152 is a lysosome localized e3 ligase with pro-apoptotic activities. it is the first e3 ligase identified so far that is involved in lysosome-related apoptosis. |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000208511100008 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2406384 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tang, Jie |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Key Lab Infect & Immun, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Songling,Wu, Wei,Wu, Yanfang,et al. Rnf152, a novel lysosome localized e3 ligase with pro-apoptotic activities[J]. Protein & cell,2010,1(7):656-663. |
| APA | Zhang, Songling.,Wu, Wei.,Wu, Yanfang.,Zheng, Jiyan.,Suo, Talin.,...&Tang, Jie.(2010).Rnf152, a novel lysosome localized e3 ligase with pro-apoptotic activities.Protein & cell,1(7),656-663. |
| MLA | Zhang, Songling,et al."Rnf152, a novel lysosome localized e3 ligase with pro-apoptotic activities".Protein & cell 1.7(2010):656-663. |
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来源：中国科学院大学
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