Synthesis and drug release in vitro of porphyran carrying 5-fluorouracil
文献类型：期刊论文
| 作者 | Zhang, Zhongshan1,2; Zhang, Quanbin1; Wang, Jing1,2; Shi, Xuelian1,2; Zhang, Jingjing1,2; Song, Houfang1,2 |
| 刊名 | Carbohydrate polymers
 |
| 出版日期 | 2010-02-11 |
| 卷号 | 79期号:3页码:628-632 |
| ISSN号 | 0144-8617 |
| 关键词 | Porphyran 5-fluorouracil Drug release In vitro |
| DOI | 10.1016/j.carbpol.2009.09.009 |
| 通讯作者 | Zhang, quanbin(qbzhang@ms.qdio.ac.cn) |
| 英文摘要 | Porphyran, the sulfated polysaccharide from red algae porphyra haitanensis, possesses excellent bioactivities, especially the immune activity. in order to provide a water-soluble macromolecule prodrug of 5-fu showing slow release of 5-fu, reducing side-effect, we employed porphyran as a drug carrier, and carried out fixation of 5-fu to porphyran at 6-position through acetyl spacer group via ester bond. the chemical characteristic and release behavior of 5-fu from the conjugate obtained were studied in vitro at 37 degrees c in three different medium. the results represented that the release mechanism of all the conjugates was a typical fickian diffusion. however, further in vivo studies on animal models are necessary to establish the efficiency of the system. (c) 2009 elsevier ltd. all rights reserved. |
| WOS关键词 | ANTITUMOR-ACTIVITY ; ACID ; CHLOROACETYLATION ; CHITOSAN |
| WOS研究方向 | Chemistry ; Polymer Science |
| WOS类目 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000273864500020 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2407151 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Quanbin |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhongshan,Zhang, Quanbin,Wang, Jing,et al. Synthesis and drug release in vitro of porphyran carrying 5-fluorouracil[J]. Carbohydrate polymers,2010,79(3):628-632. |
| APA | Zhang, Zhongshan,Zhang, Quanbin,Wang, Jing,Shi, Xuelian,Zhang, Jingjing,&Song, Houfang.(2010).Synthesis and drug release in vitro of porphyran carrying 5-fluorouracil.Carbohydrate polymers,79(3),628-632. |
| MLA | Zhang, Zhongshan,et al."Synthesis and drug release in vitro of porphyran carrying 5-fluorouracil".Carbohydrate polymers 79.3(2010):628-632. |
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来源：中国科学院大学
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