Hypocrellin b doped and ph-responsive silica nanoparticles for photodynamic therapy
文献类型：期刊论文
| 作者 | Li ZhaoBo1,2; Wang JianGuang1,2; Chen JingRong1; Lei WanHua1; Wang XueSong1; Zhang BaoWen1 |
| 刊名 | Science china-chemistry
 |
| 出版日期 | 2010-09-01 |
| 卷号 | 53期号:9页码:1994-1999 |
| 关键词 | Photodynamic therapy Ph responsive Bromocresol purple Hypocrellin b Silica nanoparticles |
| ISSN号 | 1674-7291 |
| DOI | 10.1007/s11426-010-3201-2 |
| 通讯作者 | Wang xuesong(xswang@mail.ipc.ac.cn) |
| 英文摘要 | Ph-responsive (1)o(2) photosensitizing systems may serve as selective photodynamic therapy (pdt) agents by targeting the acidic interstitial fluid of many kinds of tumors. in this work, a natural and clinically used photosensitizer (hypocrellin b, hb) and a ph indicator (bromocresol purple, bcp) were co-encapsulated in organically modified silica nanoparticles. bcp successfully regulated the (1)o(2) generation efficiency of hb through the "inner filter" effect, which shows much stronger (1)o(2) generation ability in an acidic than in a basic environment. in vitro experiments also demonstrated that hb-doped nanoparticles are effective in killing tumor cells by pdt. |
| WOS关键词 | ORGANICALLY MODIFIED SILICA ; ANTICANCER DRUGS ; SINGLET OXYGEN ; BODIPY DYES ; IN-VITRO ; DERIVATIVES ; GENERATION ; DELIVERY ; CANCER ; PHOTOSENSITIZERS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000282171900024 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2407186 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang XueSong |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li ZhaoBo,Wang JianGuang,Chen JingRong,et al. Hypocrellin b doped and ph-responsive silica nanoparticles for photodynamic therapy[J]. Science china-chemistry,2010,53(9):1994-1999. |
| APA | Li ZhaoBo,Wang JianGuang,Chen JingRong,Lei WanHua,Wang XueSong,&Zhang BaoWen.(2010).Hypocrellin b doped and ph-responsive silica nanoparticles for photodynamic therapy.Science china-chemistry,53(9),1994-1999. |
| MLA | Li ZhaoBo,et al."Hypocrellin b doped and ph-responsive silica nanoparticles for photodynamic therapy".Science china-chemistry 53.9(2010):1994-1999. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。