A novel mechanism of epigenetic regulation: nucleosome-space occupancy
文献类型：期刊论文
| 作者 | Cui, Peng1; Zhang, Lingfang1,2; Lin, Qiang1,2; Ding, Feng1; Xin, Chengqi1,2; Fang, Xiangdong1; Hu, Songnian1; Yu, Jun1 |
| 刊名 | Biochemical and biophysical research communications
 |
| 出版日期 | 2010 |
| 卷号 | 391期号:1页码:884-889 |
| 关键词 | Nucleosome Histone modification Epigenetic regulation |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2009.11.157 |
| 通讯作者 | Yu, jun() |
| 英文摘要 | Nucleosome positioning around the gene space (or transcriptional unit) plays a crucial role for gene regulation but we do not know if the spatial organization-nucleosome-space occupancy or nucleosome density in a defined sequence unit length-contributes to the regulation complexity of mammalian gene expression. using our own rmrna-seq (ribosomal rna-minus rna sequencing) and publically available chip-seq (h3) data from mouse stem cells. we discovered a non-random distribution of nucleosomes along chromosomes, and further genome-wide studies oil histone modifications, dna methylation, transcriptional activity, gene density, and base compositional dynamics, demonstrated that nucleosome-space occupancy of genomic regions-clustered genes and their intergenic spaces-show distinctive features, where a high occupancy coincides with active transcription, intensive histone modifications, poor dna methylation, and higher gc contents as compared to the nucleosome-poor regions. we therefore proposed that nucleosome-space occupancy as a novel mechanism of epigenetic gene regulation, creating a vital environment for transcriptional activation. (c) 2009 elsevier inc. all rights reserved. |
| WOS关键词 | HUMAN GENOME ; GENE-REGULATION ; CHROMATIN ; PROMOTERS ; METHYLATION ; PLURIPOTENT ; RECOGNITION ; DISTINCT ; CELLS ; MAPS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000273624500155 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2407697 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu, Jun |
| 作者单位 | 1.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genome Sci & Informat, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Peng,Zhang, Lingfang,Lin, Qiang,et al. A novel mechanism of epigenetic regulation: nucleosome-space occupancy[J]. Biochemical and biophysical research communications,2010,391(1):884-889. |
| APA | Cui, Peng.,Zhang, Lingfang.,Lin, Qiang.,Ding, Feng.,Xin, Chengqi.,...&Yu, Jun.(2010).A novel mechanism of epigenetic regulation: nucleosome-space occupancy.Biochemical and biophysical research communications,391(1),884-889. |
| MLA | Cui, Peng,et al."A novel mechanism of epigenetic regulation: nucleosome-space occupancy".Biochemical and biophysical research communications 391.1(2010):884-889. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。