Synthesis and anti-angiogenesis activities of ursolic acid derivatives
文献类型：期刊论文
| 作者 | Zhang Wen-Juan1,2; Chen Shao-Peng1; Lu Xin1; Zhou Guo-Chun1,2 |
| 刊名 | Chemical journal of chinese universities-chinese
 |
| 出版日期 | 2010-11-10 |
| 卷号 | 31期号:11页码:2206-2217 |
| ISSN号 | 0251-0790 |
| 关键词 | Ursolic acid Derivative Anti-angigenesis Antiproliferation |
| 通讯作者 | Zhou guo-chun(springzhou@yahoo.com) |
| 英文摘要 | Twenty-four derivatives of ursolic acid modified at c3 and c28 were designed and synthesized for the investigation of the structure-activity relationship of ursolic acid (1) against angiogenesis. all the compounds were characterized by (1)h nmr, (13)c nmr, ms and hr-ms. huvec was used as an angiogenesis target cell and a549, bel-7402 and mcf-7 were as cancer target cells and the antiproliferative activity was assayed by mtt method. the results show that compounds 5, 9, 12e and 14e possess the selectively antiproliferative activity of huvec, meanwhile, compounds 12a and 13h are more active than compound 1 against the proliferation of huvec. therefore, it is possible that more potent and selective angiogenesis inhibitors of ursolic acid derivatives could be discovered by suitable modification at c28 position of ursolic acid. these data suggest that ursolic acid and its derivatives represent a promising lead structural core to discover a new class of antiangiogenesis agents. |
| WOS关键词 | OLEANOLIC ACID |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | HIGHER EDUCATION PRESS |
| WOS记录号 | WOS:000285538100019 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2407819 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou Guo-Chun |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510663, Guangdong, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang Wen-Juan,Chen Shao-Peng,Lu Xin,et al. Synthesis and anti-angiogenesis activities of ursolic acid derivatives[J]. Chemical journal of chinese universities-chinese,2010,31(11):2206-2217. |
| APA | Zhang Wen-Juan,Chen Shao-Peng,Lu Xin,&Zhou Guo-Chun.(2010).Synthesis and anti-angiogenesis activities of ursolic acid derivatives.Chemical journal of chinese universities-chinese,31(11),2206-2217. |
| MLA | Zhang Wen-Juan,et al."Synthesis and anti-angiogenesis activities of ursolic acid derivatives".Chemical journal of chinese universities-chinese 31.11(2010):2206-2217. |
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来源：中国科学院大学
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