Serum proteomic profile analysis for endometrial carcinoma detection with maldi-tof ms
文献类型：期刊论文
| 作者 | Qiu, Feng1,2; Gao, Yan H.1; Jiang, Chao G.1; Tian, Ya P.1; Zhang, Xue J.1,3 |
| 刊名 | Archives of medical science
 |
| 出版日期 | 2010-04-01 |
| 卷号 | 6期号:2页码:245-252 |
| 关键词 | Serum proteomic analysis maldi-tof endometrial carcinoma serum detection model |
| ISSN号 | 1734-1922 |
| DOI | 10.5114/aoms.2010.13903 |
| 通讯作者 | Tian, ya p.(tianyp61@gmail.com) |
| 英文摘要 | Introduction: endometrial carcinoma is the one of the leading causes of terminal cancer death in women, and the best way to solve it is through an early diagnosis. serum proteomic profiling is a promising approach to classify disease versus normal and matrix-assisted laser desorption/ionization time of flight mass spectrometry (maldi-tof). this analysis is a new potential tool for the diagnosis of human diseases. the objective of our study was to assess the feasibility of mass spectrometry, based on serum proteomic pattern for the discrimination of endometrial carcinoma patients from healthy control patients. material and methods: by using 30 pre-operative endometrial carcinoma serum samples and 30 healthy controls, we generated maldi-tof protein profiles, established the serum detection model, and analyzed the data. furthermore, we validated the data and got the total sensitivity (97.6%) and specificity (100%), which could classify all the samples well and demonstrated the high, significant separation ability. results: our results indicated that high sensitivity and specificity classify endometrial carcinoma by the serum detection model and showed the potential usefulness of serum protein profiles. conclusions: from these results, we could tell that maldi-tof ms is a potential tool for diagnosing diseases by the use of serum samples and will be widely used in the future for clinical work. |
| WOS关键词 | BREAST-CANCER ; MARKER DISCOVERY ; PROSTATE-CANCER ; ESTROGENS ; PATTERNS ; WOMEN ; RISK |
| WOS研究方向 | General & Internal Medicine |
| WOS类目 | Medicine, General & Internal |
| 语种 | 英语 |
| WOS记录号 | WOS:000279340800017 |
| 出版者 | TERMEDIA PUBLISHING HOUSE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2407909 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tian, Ya P. |
| 作者单位 | 1.Chinese Peoples Liberat Army Gen Hosp, Dept Clin Biochem, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing, Peoples R China 3.Sarasota Int Trade Ctr, Sarasota, FL USA |
| 推荐引用方式 GB/T 7714 | Qiu, Feng,Gao, Yan H.,Jiang, Chao G.,et al. Serum proteomic profile analysis for endometrial carcinoma detection with maldi-tof ms[J]. Archives of medical science,2010,6(2):245-252. |
| APA | Qiu, Feng,Gao, Yan H.,Jiang, Chao G.,Tian, Ya P.,&Zhang, Xue J..(2010).Serum proteomic profile analysis for endometrial carcinoma detection with maldi-tof ms.Archives of medical science,6(2),245-252. |
| MLA | Qiu, Feng,et al."Serum proteomic profile analysis for endometrial carcinoma detection with maldi-tof ms".Archives of medical science 6.2(2010):245-252. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。