The human pluripotency gene nanog/nanogp8 is expressed in gastric cancer and associated with tumor development
文献类型：期刊论文
| 作者 | Zhang, Jingyu2; Wang, Xia1,3; Chen, Bing1; Xiao, Zhifeng1; Li, Wenmei2; Lu, Youyong2; Dai, Jianwu1 |
| 刊名 | Oncology letters
 |
| 出版日期 | 2010-05-01 |
| 卷号 | 1期号:3页码:457-463 |
| 关键词 | Nanog Nanogp8 Gastric cancer Stem cell |
| ISSN号 | 1792-1074 |
| DOI | 10.3892/ol_00000081 |
| 通讯作者 | Dai, jianwu() |
| 英文摘要 | It is well known that cancer cells exhibit characteristics similar to normal stem cells the majority of tumors frequently overexpress genes commonly found in embryonic stem cells to determine whether the pluripotency gene nanog and its retrogene, nanogp8, play a role in gastric cancer, we analyzed the nanog/nanogp8 expression profile at the mrna and protein level in primary gastric tumors our data demonstrated that overexpression of nanog/nanogp8 was consistently detected in primary tumors (75%, 30/40) compared to adjacent normal tissues (12 5%, 5/40) furthermore, nanog/nanogp8 was highly expressed in the intestinal metaplasia (60%, 24/40) and dysplasia tissues (66 7%, 20/30) compared to normal tissues these results suggest that nanog/nanogp8 exhibits potential as a biomarker and its expression may play an important role in gastric cancer development |
| WOS关键词 | GERM-CELL TUMORS ; STEM-CELLS ; NANOG ; CARCINOGENESIS ; PSEUDOGENES ; CARCINOMA ; STELLAR ; OCT4 ; GDF3 |
| WOS研究方向 | Oncology |
| WOS类目 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000284800300012 |
| 出版者 | SPANDIDOS PUBL LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2407944 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianwu |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100190, Peoples R China 2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Lab Mol Oncol,Key Lab Carcinogenesis & Translat R, Beijing, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jingyu,Wang, Xia,Chen, Bing,et al. The human pluripotency gene nanog/nanogp8 is expressed in gastric cancer and associated with tumor development[J]. Oncology letters,2010,1(3):457-463. |
| APA | Zhang, Jingyu.,Wang, Xia.,Chen, Bing.,Xiao, Zhifeng.,Li, Wenmei.,...&Dai, Jianwu.(2010).The human pluripotency gene nanog/nanogp8 is expressed in gastric cancer and associated with tumor development.Oncology letters,1(3),457-463. |
| MLA | Zhang, Jingyu,et al."The human pluripotency gene nanog/nanogp8 is expressed in gastric cancer and associated with tumor development".Oncology letters 1.3(2010):457-463. |
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来源：中国科学院大学
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