Dexh-box protein dhx30 is required for optimal function of the zinc-finger antiviral protein
文献类型：期刊论文
| 作者 | Ye, Peiying1,2; Liu, Shufeng1; Zhu, Yiping1,2; Chen, Guifang1; Gao, Guangxia1 |
| 刊名 | Protein & cell
 |
| 出版日期 | 2010-10-01 |
| 卷号 | 1期号:10页码:956-964 |
| 关键词 | Zinc-finger antiviral protein Rna helicase Dhx30 |
| ISSN号 | 1674-800X |
| DOI | 10.1007/s13238-010-0117-8 |
| 通讯作者 | Gao, guangxia(gaogx@moon.ibp.ac.cn) |
| 英文摘要 | The zinc-finger antiviral protein (zap) is a host factor that specifically inhibits the replication of certain viruses by eliminating viral mrnas in the cytoplasm. in previous studies, we demonstrated that zap directly binds to the viral mrnas and recruits the rna exosome to degrade the target rna. in this article, we provide evidence that a dexh box rna helicase, dhx30, is required for optimal antiviral activity of zap. pull-down and co-immunoprecipitation assays demonstrated that dhx30 and zap interacted with each other via their n terminal domains. downregulation of dhx30 with shrnas reduced zap's antiviral activity. these data implicate that dhx30 is a cellular factor involved in the antiviral function of zap. |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000208511600011 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2407965 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Gao, Guangxia |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Ctr Infect & Immun, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Peiying,Liu, Shufeng,Zhu, Yiping,et al. Dexh-box protein dhx30 is required for optimal function of the zinc-finger antiviral protein[J]. Protein & cell,2010,1(10):956-964. |
| APA | Ye, Peiying,Liu, Shufeng,Zhu, Yiping,Chen, Guifang,&Gao, Guangxia.(2010).Dexh-box protein dhx30 is required for optimal function of the zinc-finger antiviral protein.Protein & cell,1(10),956-964. |
| MLA | Ye, Peiying,et al."Dexh-box protein dhx30 is required for optimal function of the zinc-finger antiviral protein".Protein & cell 1.10(2010):956-964. |
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来源：中国科学院大学
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