Synthesis, radiolabelling and in vitro stability study of tc-99m(co)(3)(+) labeled dendrimer pamam-folic acid conjugate
文献类型：期刊论文
| 作者 | Zhang Yuanqing1,2; Xu Xiaoping1,2; Sun Yanhong1; Shen Yumei1,3 |
| 刊名 | Chinese journal of chemistry
 |
| 出版日期 | 2010-12-01 |
| 卷号 | 28期号:12页码:2447-2450 |
| 关键词 | Dendrimer Pamam Tc-99m(co)(3)(+) Radiolabelled Folic acid |
| ISSN号 | 1001-604X |
| 通讯作者 | Shen yumei(shenyumei@sinap.ac.cn) |
| 英文摘要 | Dendrimer polyamidoamine generation five-folic acid conjugate was synthesesed and radiolabelled with fac-[tc-99m(co)(3)(h2o)(3)](+), its in vitro stability was evaluated further. both of the labeling yield and radiochemical purity of the g5-fa-dtpa-tc-99m(co)(3) conjugate exceeded 95%. more than 95.7% and 93.1% of the conjugate still keeps its original structure in pbs and new-born calf serum solution respectively. |
| WOS关键词 | BIOMEDICAL APPLICATIONS ; DRUG-DELIVERY ; CANCER-CELLS ; MACROMOLECULES ; BIOMOLECULES ; NANODEVICE ; THERAPY ; COMPLEX ; LIGAND |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000286086100020 |
| 出版者 | WILEY-BLACKWELL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2408306 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shen Yumei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Res Ctr Radiopharmaceut, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang Yuanqing,Xu Xiaoping,Sun Yanhong,et al. Synthesis, radiolabelling and in vitro stability study of tc-99m(co)(3)(+) labeled dendrimer pamam-folic acid conjugate[J]. Chinese journal of chemistry,2010,28(12):2447-2450. |
| APA | Zhang Yuanqing,Xu Xiaoping,Sun Yanhong,&Shen Yumei.(2010).Synthesis, radiolabelling and in vitro stability study of tc-99m(co)(3)(+) labeled dendrimer pamam-folic acid conjugate.Chinese journal of chemistry,28(12),2447-2450. |
| MLA | Zhang Yuanqing,et al."Synthesis, radiolabelling and in vitro stability study of tc-99m(co)(3)(+) labeled dendrimer pamam-folic acid conjugate".Chinese journal of chemistry 28.12(2010):2447-2450. |
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来源：中国科学院大学
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