Cutting edge: ctla-4-b7 interaction suppresses th17 cell differentiation
文献类型：期刊论文
| 作者 | Ying, Haiyan1,2,3,5; Yang, Lifen1,4,5; Qiao, Guilin1; Li, Zhenping1; Zhang, Li1; Yin, Fei4; Xie, Dong2; Zhang, Jian1,5,6 |
| 刊名 | Journal of immunology
 |
| 出版日期 | 2010-08-01 |
| 卷号 | 185期号:3页码:1375-1378 |
| ISSN号 | 0022-1767 |
| DOI | 10.4049/jimmunol.0903369 |
| 通讯作者 | Zhang, jian(jzhang@medicine.bsd.uchicago.edu) |
| 英文摘要 | Th cells that produce il-17 (th17 cells) are a distinct subset of th cells implicated in several autoimmune diseases. although cd28-b7 interaction has been shown to be involved in th17 differentiation in vitro, the role of ctla-4 in controlling th17 development is completely unknown. we report in this paper that blocking the ctla-4-b7 interaction potentiates th17 cell differentiation in vitro and in vivo. furthermore, blocking ctla-4-b7 interaction in vivo confers the susceptibility of experimental autoimmune myocarditis to cd28(-/-) mice or increases the severity of experimental autoimmune myocarditis in wild-type mice. the enhanced disease susceptibility is mediated by heightened th17 responses. with these results, we are the first to demonstrate that ctla-4-b7 interaction inhibits th17 differentiation in vitro and in vivo and suppresses th17-mediated autoimmunity. the journal of immunology, 2010, 185: 1375-1378. |
| WOS关键词 | T-CELLS ; AUTOIMMUNE MYOCARDITIS ; COSTIMULATION ; ACTIVATION ; MICE ; LYMPHOPROLIFERATION ; INTERLEUKIN-17 ; INDUCTION |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000280177400011 |
| 出版者 | AMER ASSOC IMMUNOLOGISTS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2408544 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Jian |
| 作者单位 | 1.Univ Chicago, Dept Med, Nephrol Sect, Chicago, IL 60637 USA 2.Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Lab Mol Canc Biol, Beijing 100864, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China 4.Cent S Univ, Dept Pediat, Xiangya Hosp, Changsha, Hunan, Peoples R China 5.Univ Chicago, Dept Med, Comm Immunol, Chicago, IL 60637 USA 6.Univ Chicago, Dept Med, Comm Mol Med, Chicago, IL 60637 USA |
| 推荐引用方式 GB/T 7714 | Ying, Haiyan,Yang, Lifen,Qiao, Guilin,et al. Cutting edge: ctla-4-b7 interaction suppresses th17 cell differentiation[J]. Journal of immunology,2010,185(3):1375-1378. |
| APA | Ying, Haiyan.,Yang, Lifen.,Qiao, Guilin.,Li, Zhenping.,Zhang, Li.,...&Zhang, Jian.(2010).Cutting edge: ctla-4-b7 interaction suppresses th17 cell differentiation.Journal of immunology,185(3),1375-1378. |
| MLA | Ying, Haiyan,et al."Cutting edge: ctla-4-b7 interaction suppresses th17 cell differentiation".Journal of immunology 185.3(2010):1375-1378. |
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来源：中国科学院大学
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