Superoxide anion, uncoupling proteins and alzheimer's disease
文献类型：期刊论文
| 作者 | Wu, Zhaofei1,2; Zhao, Yan3; Zhao, Baolu1 |
| 刊名 | Journal of clinical biochemistry and nutrition
 |
| 出版日期 | 2010-05-01 |
| 卷号 | 46期号:3页码:187-194 |
| 关键词 | Superoxide anion Uncoupling protein Alzheimer's disease Oxidative stress Neurodegeneration |
| ISSN号 | 0912-0009 |
| 通讯作者 | Zhao, baolu(zhaobl@sun5.ibp.ac.cn) |
| 英文摘要 | Superoxide anion is the first generated reactive oxygen species (ros) after oxygen enters living cells. it was once considered to be highly deleterious to cell functions and aging. therefore, antioxidants were suggested to prevent aging and degenerative diseases. however, superoxide signaling has been shown in many physiological responses such as transcriptional regulation, protein activation, bioenergy output, cell proliferation and apoptosis. the uncoupling proteins (ucps) are a family of mitochondrial anion-carrier proteins located in the inner mitochondrial membrane and are considered to reduce the generation of superoxide anion through the mitochondrial mild uncoupling. ucps are important in prevention of mitochondrial excessive generation of ros, transfer of mitochondrial substrates, mitochondrial calcium uniport and regulation of thermogenesis. superoxide anion and uncoupling proteins are linked to alzheimer's disease in mitochondria. simultaneous disorders of superoxide and uncoupling proteins create the conditions for neuronal oxidative damages. on the one hand, sustained oxidative damage causes neuronal apoptosis and eventually, accumulated neuronal apoptosis, leading to exacerbations of alzheimer's disease. on the other hand, our study has shown that ucp2 and ucp4 have important impact on mitochondrial calcium concentration of nerve cells, suggesting that their abnormal expression may involve in the pathogenesis of alzheimer's disease. |
| WOS关键词 | MEMBRANE CA-ATPASE ; PROLYL ISOMERASE PIN1 ; SMOOTH-MUSCLE-CELLS ; OXIDATIVE STRESS ; MITOCHONDRIAL DYSFUNCTION ; HYDROGEN-PEROXIDE ; INDUCED APOPTOSIS ; GENE-EXPRESSION ; DIFFERENTIATION ; BETA |
| WOS研究方向 | Nutrition & Dietetics |
| WOS类目 | Nutrition & Dietetics |
| 语种 | 英语 |
| WOS记录号 | WOS:000278903500001 |
| 出版者 | JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2408715 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhao, Baolu |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China 3.Harbin Inst Technol, Dept Food Sci & Technol, Weihai 264209, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Zhaofei,Zhao, Yan,Zhao, Baolu. Superoxide anion, uncoupling proteins and alzheimer's disease[J]. Journal of clinical biochemistry and nutrition,2010,46(3):187-194. |
| APA | Wu, Zhaofei,Zhao, Yan,&Zhao, Baolu.(2010).Superoxide anion, uncoupling proteins and alzheimer's disease.Journal of clinical biochemistry and nutrition,46(3),187-194. |
| MLA | Wu, Zhaofei,et al."Superoxide anion, uncoupling proteins and alzheimer's disease".Journal of clinical biochemistry and nutrition 46.3(2010):187-194. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。