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Chinese Academy of Sciences Institutional Repositories Grid
Preparation and swelling properties of ph-sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release

文献类型:期刊论文

作者Wang, Qin1,2; Xie, Xiaoling3; Zhang, Xiaowei3; Zhang, Junping1; Wang, Aiqin1
刊名International journal of biological macromolecules
出版日期2010-04-01
卷号46期号:3页码:356-362
关键词Composite hydrogel Bead Vermiculite Ph-sensitive Controlled release
ISSN号0141-8130
DOI10.1016/j.ijbiomac.2010.01.009
通讯作者Wang, aiqin()
英文摘要A series of ph-sensitive composite hydrogel beads, chitosan-g-poly (acrylic acid)/vermiculite/sodium alginate (cts-g-paa/vmt/sa), was prepared using cts-g-paa/vmt composite and sa by ca(2+) as the crosslinking agent the structure and morphologies of the developed composite hydrogel beads were characterized by fourier transform infrared spectroscopy and scanning electron microscopy the swelling properties and ph-sensitivity of the beads were investigated. in addition, the drug loading and controlled release behaviors of the beads were also evaluated using diclofenac sodium (ds) as the model drug in stimulated gastric fluids (ph 2 1) and intestinal fluids (ph 6 8) the results indicate that the composite hydrogel beads showed good ph-sensitivity the release rate of the drug from the composite hydrogel beads is remarkably slowed down, which indicated that incorporating vmt into the composite hydrogel beads can improve the burst release effect of the drug (c) 2010 elsevier b v. all rights reserved
WOS关键词DRUG-DELIVERY SYSTEMS ; IN-VITRO ; ORAL DELIVERY ; NANOPARTICLES ; VERMICULITE ; CLAYS ; MONTMORILLONITE ; MICROSPHERES ; HYDROTALCITE ; BEHAVIOR
WOS研究方向Biochemistry & Molecular Biology
WOS类目Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000276381300013
出版者ELSEVIER SCIENCE BV
URI标识http://www.irgrid.ac.cn/handle/1471x/2408804
专题中国科学院大学
通讯作者Wang, Aiqin
作者单位1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Lanzhou Univ, Hosp 1, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714
Wang, Qin,Xie, Xiaoling,Zhang, Xiaowei,et al. Preparation and swelling properties of ph-sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release[J]. International journal of biological macromolecules,2010,46(3):356-362.
APA Wang, Qin,Xie, Xiaoling,Zhang, Xiaowei,Zhang, Junping,&Wang, Aiqin.(2010).Preparation and swelling properties of ph-sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release.International journal of biological macromolecules,46(3),356-362.
MLA Wang, Qin,et al."Preparation and swelling properties of ph-sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release".International journal of biological macromolecules 46.3(2010):356-362.

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来源:中国科学院大学

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