Preparation and swelling properties of ph-sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release
文献类型：期刊论文
| 作者 | Wang, Qin1,2; Xie, Xiaoling3; Zhang, Xiaowei3; Zhang, Junping1; Wang, Aiqin1 |
| 刊名 | International journal of biological macromolecules
 |
| 出版日期 | 2010-04-01 |
| 卷号 | 46期号:3页码:356-362 |
| 关键词 | Composite hydrogel Bead Vermiculite Ph-sensitive Controlled release |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2010.01.009 |
| 通讯作者 | Wang, aiqin() |
| 英文摘要 | A series of ph-sensitive composite hydrogel beads, chitosan-g-poly (acrylic acid)/vermiculite/sodium alginate (cts-g-paa/vmt/sa), was prepared using cts-g-paa/vmt composite and sa by ca(2+) as the crosslinking agent the structure and morphologies of the developed composite hydrogel beads were characterized by fourier transform infrared spectroscopy and scanning electron microscopy the swelling properties and ph-sensitivity of the beads were investigated. in addition, the drug loading and controlled release behaviors of the beads were also evaluated using diclofenac sodium (ds) as the model drug in stimulated gastric fluids (ph 2 1) and intestinal fluids (ph 6 8) the results indicate that the composite hydrogel beads showed good ph-sensitivity the release rate of the drug from the composite hydrogel beads is remarkably slowed down, which indicated that incorporating vmt into the composite hydrogel beads can improve the burst release effect of the drug (c) 2010 elsevier b v. all rights reserved |
| WOS关键词 | DRUG-DELIVERY SYSTEMS ; IN-VITRO ; ORAL DELIVERY ; NANOPARTICLES ; VERMICULITE ; CLAYS ; MONTMORILLONITE ; MICROSPHERES ; HYDROTALCITE ; BEHAVIOR |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000276381300013 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2408804 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Aiqin |
| 作者单位 | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Lanzhou Univ, Hosp 1, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qin,Xie, Xiaoling,Zhang, Xiaowei,et al. Preparation and swelling properties of ph-sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release[J]. International journal of biological macromolecules,2010,46(3):356-362. |
| APA | Wang, Qin,Xie, Xiaoling,Zhang, Xiaowei,Zhang, Junping,&Wang, Aiqin.(2010).Preparation and swelling properties of ph-sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release.International journal of biological macromolecules,46(3),356-362. |
| MLA | Wang, Qin,et al."Preparation and swelling properties of ph-sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release".International journal of biological macromolecules 46.3(2010):356-362. |
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来源：中国科学院大学
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