The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding bdnf
文献类型：期刊论文
| 作者 | Liang, Weibang2; Han, Qianqian1,3; Jin, Wei2; Xiao, Zhifeng1; Huang, Jingchun4; Ni, Hongbin2; Chen, Bing1; Kong, Jie2; Wu, Jun2; Dai, Jianwu1 |
| 刊名 | Biomaterials
 |
| 出版日期 | 2010-11-01 |
| 卷号 | 31期号:33页码:8634-8641 |
| 关键词 | Collagen Drug delivery Nerve regeneration Wound healing |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2010.07.084 |
| 通讯作者 | Dai, jianwu(jwdai@genetics.ac.cn) |
| 英文摘要 | Spinal cord crushed injury is clinically common. promoting targeted neural regeneration at the crushed site of spinal cord could be important for the repair. it has been demonstrated in our previous work that native human bdnf fused with a collagen-binding domain (cbd-bdnf) can bind to collagen specifically to exert the neurotrophic effect on promoting axonal regeneration. after injury, collagen is highly accumulated at the injury site. we thus speculate that cbd-bdnf will bind to the extracellular matrix collagen and concentrate at the injury site to improve the therapy. using the rat spinal cord crushed injury model, we have found that cbd-bdnf by one-time intrathecally injection could be retained and concentrated at the injury site for a longer time than native bdnf without collagen-binding domain. cbd-bdnf could promote better neural regeneration and locomotion recovery. (c) 2010 elsevier ltd. all rights reserved. |
| WOS关键词 | MYELIN-ASSOCIATED GLYCOPROTEIN ; ADULT-RAT ; FUNCTIONAL RECOVERY ; COMPRESSION INJURY ; NERVE GROWTH ; AXON GROWTH ; IN-VITRO ; NEURONS ; REGENERATION ; CELLS |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000283912700014 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2409165 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianwu |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100080, Peoples R China 2.Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Neurosurg, Nanjing 210008, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China 4.China State Drug Adm SFDA, Shandong Qual Inspect Ctr Med Devices, Jinan 250101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Weibang,Han, Qianqian,Jin, Wei,et al. The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding bdnf[J]. Biomaterials,2010,31(33):8634-8641. |
| APA | Liang, Weibang.,Han, Qianqian.,Jin, Wei.,Xiao, Zhifeng.,Huang, Jingchun.,...&Dai, Jianwu.(2010).The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding bdnf.Biomaterials,31(33),8634-8641. |
| MLA | Liang, Weibang,et al."The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding bdnf".Biomaterials 31.33(2010):8634-8641. |
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来源：中国科学院大学
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