The association between common genetic variation in the fto gene and metabolic syndrome in han chinese
文献类型：期刊论文
| 作者 | Wang Tong1,2,3; Huang Yi4,5; Xiao Xin-hua1,2; Wang Duen-mei4; Diao Cheng-ming1,2; Zhang Feng4; Xu Ling-ling1,2; Zhang Yong-biao4; Li Wen-hui1,2; Zhang Li-li4,5 |
| 刊名 | Chinese medical journal
 |
| 出版日期 | 2010-07-20 |
| 卷号 | 123期号:14页码:1852-1858 |
| 关键词 | Fat mass and obesity associated gene Metabolic syndrome Chinese Single nucleotide polymorphisms |
| ISSN号 | 0366-6999 |
| DOI | 10.3760/cma.j.issn.0366-6999.2010.14.005 |
| 通讯作者 | Xiao xin-hua(xiaoxinhua@medmail.com.cn) |
| 英文摘要 | Background genome-wide association studies for type 2 diabetes mellitus (t2dm) identified fto gene as a locus conferring increased risk for common obesity in many populations with european ancestry. however, the involvement of fto gene in obesity or t2dm related metabolic traits has not been consistently established in chinese populations. the objective of this study was to investigate the association of fto genetic polymorphisms with metabolic syndrome (mets) in han chinese. methods we tested 41 fto single nucleotide polymorphisms (snps) for association between fto and mets-related traits. there were a total of 236 unrelated subjects (108 cases and 128 controls), grouped according to the international diabetes federation (idf) criteria. results of the 41 snps examined, only snp rs8047395 exhibited statistical significance (p=0.026) under a recessive model, after bonferroni adjustment for multiple testing (or 1.64, 95% c/ 1.11-2.42; p=0.014). the common distributions of this polymorphism among chinese-with a minor allele frequency (maf) of 36% in the control group versus 48% in the mets group-greatly improved our test power in a relatively small sample size for an association study. previously identified obesity- (or t2dm-) associated fto snps were less common in han chinese and were not associated with mets in this study. no significant associations were found between our fto snps and any endophenotypes of mets. conclusions a more common risk-conferring variant of fto for mets was identified in han chinese. our study substantiated that genetic variations in fto locus are involved in the pathogenesis of mets. chin med j 2010;123(14):1852-1858 |
| WOS关键词 | FAT MASS ; CARDIOVASCULAR-DISEASE ; SCIENTIFIC STATEMENT ; EXTREME OBESITY ; ADULT OBESITY ; VARIANTS ; POPULATION ; TRAITS ; RISK ; ATHEROSCLEROSIS |
| WOS研究方向 | General & Internal Medicine |
| WOS类目 | Medicine, General & Internal |
| 语种 | 英语 |
| WOS记录号 | WOS:000280433700005 |
| 出版者 | CHINESE MEDICAL ASSOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2409290 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xiao Xin-hua |
| 作者单位 | 1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol, Minist Hlth,Key Lab Endocrinol, Beijing 100730, Peoples R China 2.Peking Union Med Coll, Beijing 100730, Peoples R China 3.305 Hosp Chinese Peoples Liberat Army, Dept Endocrinol, Beijing 100017, Peoples R China 4.Chinese Acad Sci, Beijing Inst Genom, Beijing 100029, Peoples R China 5.Chinese Acad Sci, Grad Univ, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Tong,Huang Yi,Xiao Xin-hua,et al. The association between common genetic variation in the fto gene and metabolic syndrome in han chinese[J]. Chinese medical journal,2010,123(14):1852-1858. |
| APA | Wang Tong.,Huang Yi.,Xiao Xin-hua.,Wang Duen-mei.,Diao Cheng-ming.,...&Zhang Qian.(2010).The association between common genetic variation in the fto gene and metabolic syndrome in han chinese.Chinese medical journal,123(14),1852-1858. |
| MLA | Wang Tong,et al."The association between common genetic variation in the fto gene and metabolic syndrome in han chinese".Chinese medical journal 123.14(2010):1852-1858. |
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来源：中国科学院大学
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