Synthesis of galabiose-chitosan conjugate as potent inhibitor of streptococcus suis adhesion
文献类型：期刊论文
| 作者 | Xu, Yaozu1,2; Fan, Hongjie3; Lu, Chengping3; Gao, George F.1; Li, Xuebing1 |
| 刊名 | Biomacromolecules
 |
| 出版日期 | 2010-07-12 |
| 卷号 | 11期号:7页码:1701-1704 |
| ISSN号 | 1525-7797 |
| DOI | 10.1021/bm100289v |
| 通讯作者 | Li, xuebing(lixb@im.ac.cn) |
| 英文摘要 | The aim of this work is to construct a safe and effective drug candidate against streptococcus suis infection. a panel of chitosan-based polymer conjugates with branched galabiose (gal alpha 1-4gal) side chains was synthesized as inhibitors of s. suis adhesion. the synthesis was achieved by using an aldehyde-functionalized galabiose derivative to graft it onto chitosan amino groups. structural compositions of the conjugates were verified by (1)h nmr spectroscopy and chn elemental analyses. potent inhibitory activities of the conjugates against s. suis adhesion to human erythrocytes were determined at low nanomolar concentration by hai assay. an spr study revealed a high affinity binding (k(d) = 39.6 nm) of the conjugate with bsi-b(4) lectin. by using biocompatible chitosan as the scaffold for presenting s. suis-specific galabiose units, as well as the concise route tailored for the conjugate syntheses, the present study provides a practical way for explorations of new anti-s. suis therapies. |
| WOS关键词 | NANOMOLAR CONCENTRATION ; DERIVATIVES ; MECHANISMS ; ACID |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000279679300001 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2409411 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, Xuebing |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Pathogen Microbiol & Immunol, Inst Microbiol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Nanjing Agr Univ, Key Lab Anim Dis Diagnost & Immunol, Minist Agr, Nanjing 210095, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Yaozu,Fan, Hongjie,Lu, Chengping,et al. Synthesis of galabiose-chitosan conjugate as potent inhibitor of streptococcus suis adhesion[J]. Biomacromolecules,2010,11(7):1701-1704. |
| APA | Xu, Yaozu,Fan, Hongjie,Lu, Chengping,Gao, George F.,&Li, Xuebing.(2010).Synthesis of galabiose-chitosan conjugate as potent inhibitor of streptococcus suis adhesion.Biomacromolecules,11(7),1701-1704. |
| MLA | Xu, Yaozu,et al."Synthesis of galabiose-chitosan conjugate as potent inhibitor of streptococcus suis adhesion".Biomacromolecules 11.7(2010):1701-1704. |
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来源：中国科学院大学
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