Highly enantioselective construction of spiro[4h-pyran-3,3 '-oxindoles] through a domino knoevenagel/michael/cyclization sequence catalyzed by cupreine
文献类型：期刊论文
| 作者 | Chen, Wen-Bing1,2; Wu, Zhi-Jun2,3; Pei, Qing-Lan1,2; Cun, Lin-Feng1; Zhang, Xiao-Mei1; Yuan, Wei-Cheng1 |
| 刊名 | Organic letters
 |
| 出版日期 | 2010-07-16 |
| 卷号 | 12期号:14页码:3132-3135 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol1009224 |
| 通讯作者 | Yuan, wei-cheng() |
| 英文摘要 | The first enantioselective organocatalytic two- and three-component reactions via a domino knoevenagel/michael/cyclization sequence with cupreine as catalyst have been developed. a wide range of optically active spiro[4h-pyran-3,3'-oxindoles] were obtained in excellent yields (up to 99%) with good to excellent enantioselectivities (up to 97%) from simple and readily available starting materials under mild reaction conditions. these heterocyclic spirooxindoles will provide promising candidates for chemical biology and drug discovery. |
| WOS关键词 | ANNULATED HETEROCYCLIC-SYSTEMS ; ONE-POT SYNTHESIS ; SPIROCYCLIC OXINDOLES ; CONJUGATE ADDITIONS ; STEREOSELECTIVE-SYNTHESIS ; QUATERNARY STEREOCENTERS ; MULTICOMPONENT REACTIONS ; TERTIARY STEREOCENTERS ; EFFICIENT SYNTHESIS ; CINCHONA ALKALOIDS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000279569600005 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2409612 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yuan, Wei-Cheng |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Wen-Bing,Wu, Zhi-Jun,Pei, Qing-Lan,et al. Highly enantioselective construction of spiro[4h-pyran-3,3 '-oxindoles] through a domino knoevenagel/michael/cyclization sequence catalyzed by cupreine[J]. Organic letters,2010,12(14):3132-3135. |
| APA | Chen, Wen-Bing,Wu, Zhi-Jun,Pei, Qing-Lan,Cun, Lin-Feng,Zhang, Xiao-Mei,&Yuan, Wei-Cheng.(2010).Highly enantioselective construction of spiro[4h-pyran-3,3 '-oxindoles] through a domino knoevenagel/michael/cyclization sequence catalyzed by cupreine.Organic letters,12(14),3132-3135. |
| MLA | Chen, Wen-Bing,et al."Highly enantioselective construction of spiro[4h-pyran-3,3 '-oxindoles] through a domino knoevenagel/michael/cyclization sequence catalyzed by cupreine".Organic letters 12.14(2010):3132-3135. |
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来源：中国科学院大学
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