Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites
文献类型：期刊论文
| 作者 | Gao, Hong1; Zhuo, Ying1,2; Ashforth, Elizabeth1; Zhang, Lixin1 |
| 刊名 | Protein & cell
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 1期号:7页码:621-626 |
| 关键词 | Synthetic biology Reduced-genome Secondary metabolite |
| ISSN号 | 1674-800X |
| DOI | 10.1007/s13238-010-0073-3 |
| 通讯作者 | Zhang, lixin(lzhang03@gmail.com) |
| 英文摘要 | Synthetic biology aims to design and build new biological systems with desirable properties, providing the foundation for the biosynthesis of secondary metabolites. the most prominent representation of synthetic biology has been used in microbial engineering by recombinant dna technology. however, there are advantages of using a deleted host, and therefore an increasing number of biotechnology studies follow similar strategies to dissect cellular networks and construct genome-reduced microbes. this review will give an overview of the strategies used for constructing and engineering reduced-genome factories by synthetic biology to improve production of secondary metabolites. |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000208511100005 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2409927 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Lixin |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Hong,Zhuo, Ying,Ashforth, Elizabeth,et al. Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites[J]. Protein & cell,2010,1(7):621-626. |
| APA | Gao, Hong,Zhuo, Ying,Ashforth, Elizabeth,&Zhang, Lixin.(2010).Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites.Protein & cell,1(7),621-626. |
| MLA | Gao, Hong,et al."Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites".Protein & cell 1.7(2010):621-626. |
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来源：中国科学院大学
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