Inhibitory effects on bacterial growth and beta-ketoacyl-acp reductase by different species of maple leaf extracts and tannic acid
文献类型：期刊论文
| 作者 | Wu, Dan1; Wu, Xiao-Dong2; You, Xue-Fu3; Ma, Xiao-Feng1; Tian, Wei-Xi1 |
| 刊名 | Phytotherapy research
 |
| 出版日期 | 2010 |
| 卷号 | 24页码:S35-s41 |
| 关键词 | Antibacteria Maple leaves Tannic acid Beta-ketoacyl-acp reductase (fabg) Enzyme inhibition |
| ISSN号 | 0951-418X |
| DOI | 10.1002/ptr.2873 |
| 通讯作者 | Tian, wei-xi(tianweixi@gucas.ac.cn) |
| 英文摘要 | It is important to develop new antibiotics aimed at novel targets. the investigation found that the leaf extracts from five maples (acerplatanoides, acer campestre, acer rubrum, acer saccharum and acer truncatum bunge collected in denmark, canada and china) and their component tannic acid displayed antibacterial ability against 24 standard bacteria strains with the minimum inhibitory concentration of 0.3-8.0 mg/ml. unlike the standard antibiotic levofloxacin (lfx), these samples inhibited gram-positive bacteria more effectively than they inhibited gram-negative bacteria. these samples effectively inhibited two antidrug bacterial strains. the results show that these samples inhibit bacteria by a different mechanism from lfx. these samples potently inhibited beta-ketoacyl-acp reductase (fabg), which is an important enzyme in bacterial fatty acid synthesis. tannic acid showed the strongest inhibition on fabg with a half inhibition concentration of 0.78 mu m (0.81 mu g/ml). furthermore, tannic acid and two maple leaf extracts showed time-dependent irreversible inhibition of fabg. these three samples also exhibited better inhibition on bacteria. it is suggested that fabg is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of fabg are important for the antibacterial effect. copyright (c) 2009 john wiley & sons, ltd. |
| WOS关键词 | CARRIER PROTEIN REDUCTASE ; MYCOBACTERIUM-TUBERCULOSIS ; ANTIBIOTIC PROPERTIES ; ESCHERICHIA-COLI ; BIOSYNTHESIS ; DISCOVERY ; SUBSTRATE ; TRICLOSAN ; TARGETS ; FABF |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000279800800007 |
| 出版者 | JOHN WILEY & SONS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2409954 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tian, Wei-Xi |
| 作者单位 | 1.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Gen Off Acad Div, Beijing, Peoples R China 3.Inst Med Biotechnol, Dept Pharmacol & Toxicol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Dan,Wu, Xiao-Dong,You, Xue-Fu,et al. Inhibitory effects on bacterial growth and beta-ketoacyl-acp reductase by different species of maple leaf extracts and tannic acid[J]. Phytotherapy research,2010,24:S35-s41. |
| APA | Wu, Dan,Wu, Xiao-Dong,You, Xue-Fu,Ma, Xiao-Feng,&Tian, Wei-Xi.(2010).Inhibitory effects on bacterial growth and beta-ketoacyl-acp reductase by different species of maple leaf extracts and tannic acid.Phytotherapy research,24,S35-s41. |
| MLA | Wu, Dan,et al."Inhibitory effects on bacterial growth and beta-ketoacyl-acp reductase by different species of maple leaf extracts and tannic acid".Phytotherapy research 24(2010):S35-s41. |
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来源：中国科学院大学
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