Mechanism of inhibiting type i interferon induction by hepatitis b virus x protein
文献类型：期刊论文
| 作者 | Jiang, Junyi1,2; Tang, Hong1 |
| 刊名 | Protein & cell
 |
| 出版日期 | 2010-12-01 |
| 卷号 | 1期号:12页码:1106-1117 |
| 关键词 | Hepatitis b virus (hbv) Hbv x protein (hbx) Deubiquitination Type i interferon |
| ISSN号 | 1674-800X |
| DOI | 10.1007/s13238-010-0141-8 |
| 通讯作者 | Tang, hong(tanghong@moon.ibp.ac.cn) |
| 英文摘要 | Hepatitis b virus (hbv) is regarded as a stealth virus, invading and replicating efficiently in human liver undetected by host innate antiviral immunity. here, we show that type i interferon (ifn) induction but not its downstream signaling is blocked by hbv replication in hepg2.2.15 cells. this effect may be partially due to hbv x protein (hbx), which impairs ifn beta promoter activation by both sendai virus (sev) and components implicated in signaling by viral sensors. as a deubiquitinating enzyme (dub), hbx cleaves lys63-linked polyubiquitin chains from many proteins except tank-binding kinase 1 (tbk1). it binds and deconjugates retinoic acid-inducible gene i (rig i) and tnf receptor-associated factor 3 (traf3), causing their dissociation from the downstream adaptor cardif or tbk1 kinase. in addition to rig i and traf3, hbx also interacts with cardif, trif, nemo, tbk1, inhibitor of kappa light polypeptide gene enhancer in b-cells, kinase epsilon (ikki) and interferon regulatory factor 3 (irf3). our data indicate that multiple points of signaling pathways can be targeted by hbx to negatively regulate production of type i ifn. |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000208511900008 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2410690 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Key Lab Infect & Immun, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Junyi,Tang, Hong. Mechanism of inhibiting type i interferon induction by hepatitis b virus x protein[J]. Protein & cell,2010,1(12):1106-1117. |
| APA | Jiang, Junyi,&Tang, Hong.(2010).Mechanism of inhibiting type i interferon induction by hepatitis b virus x protein.Protein & cell,1(12),1106-1117. |
| MLA | Jiang, Junyi,et al."Mechanism of inhibiting type i interferon induction by hepatitis b virus x protein".Protein & cell 1.12(2010):1106-1117. |
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来源：中国科学院大学
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