Anti-resorptive effect of pilose antler blood (cervus nippon temminck) in ovariectomized rats
文献类型：期刊论文
| 作者 | Yang, Jian-Hong1,2; Cao, Yi2,3; Wang, Rui-Lin2; Fei, Yu-Rong2; Zhang, Hui2,4; Feng, Pu4; Liu, Jing1 |
| 刊名 | Indian journal of experimental biology
 |
| 出版日期 | 2010-06-01 |
| 卷号 | 48期号:6页码:554-558 |
| 关键词 | Bone mineral density 17 beta-estradiol Insulin-like growth factor-1 Osteoporosis Pilose antler blood Testosterone |
| ISSN号 | 0019-5189 |
| 通讯作者 | Liu, jing() |
| 英文摘要 | Anti-bone resorption activity of pilose antler blood (cervus nippon temminck) were evaluated in ovariectomized wistar rats. the rats were randomly divided into sham operated group (sham), ovariectomized group (ovx) and pilose antler blood treated group. the ovariectomized rats were treated with pilose antler blood orally in 4000 mu l/kg daily doses for 10 weeks. compared with sham group, serum 17 beta-estradiol level decreased significantly and osteocalcin level increased significantly in ovx group, indicating successful model of osteoporosis. the experiments showed that the bone mineral density of the lumbar spine and left femur in ovx group decreased remarkably compared to sham group but normalized by treatment with pilose antler blood. additionally, serum levels of insulin-like growth factor-land testosterone were lower obviously in ovx group than those in sham group but preserved by pilose antler blood treatment. however, no obvious changes in serum levels of calcium, phosphorus, total alkaline phosphatase and osteoprotegerin were observed among three groups. these results suggested that administration of pilose antler blood was effective in alleviating osteoporosis in ovariectomized rats. |
| WOS关键词 | GROWTH-FACTOR-I ; ESTROGEN-RECEPTOR-ALPHA ; OSTEOBLAST-LIKE CELLS ; BONE LOSS ; IGF-I ; THERAPY ; HORMONE ; MICE ; EXPRESSION ; PROLIFERATION |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| WOS类目 | Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000278586800005 |
| 出版者 | NATL INST SCIENCE COMMUNICATION-NISCAIR |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2411257 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Jing |
| 作者单位 | 1.Univ Sci & Technol China, Sch Life Sci, Anhua 230026, Peoples R China 2.CAS, Grad Univ, Sch Life Sci, Beijing 100049, Peoples R China 3.Jiling Univ, Sch Life Sci, Changchun 130000, Peoples R China 4.Tsinghua Univ, Yu Quan Hosp, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Jian-Hong,Cao, Yi,Wang, Rui-Lin,et al. Anti-resorptive effect of pilose antler blood (cervus nippon temminck) in ovariectomized rats[J]. Indian journal of experimental biology,2010,48(6):554-558. |
| APA | Yang, Jian-Hong.,Cao, Yi.,Wang, Rui-Lin.,Fei, Yu-Rong.,Zhang, Hui.,...&Liu, Jing.(2010).Anti-resorptive effect of pilose antler blood (cervus nippon temminck) in ovariectomized rats.Indian journal of experimental biology,48(6),554-558. |
| MLA | Yang, Jian-Hong,et al."Anti-resorptive effect of pilose antler blood (cervus nippon temminck) in ovariectomized rats".Indian journal of experimental biology 48.6(2010):554-558. |
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来源：中国科学院大学
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