Involvement of lysosomes in the early stages of axon degeneration
文献类型：期刊论文
| 作者 | Zheng, Jin1,3; Yan, Tingting1,2; Feng, Yan1,2; Zhai, Qiwei1,2 |
| 刊名 | Neurochemistry international
 |
| 出版日期 | 2010-02-01 |
| 卷号 | 56期号:3页码:516-521 |
| 关键词 | Lysosomal disruption Mitochondrial membrane potential Axon degeneration Wld(s) Lysosomal inhibitors |
| ISSN号 | 0197-0186 |
| DOI | 10.1016/j.neuint.2009.12.012 |
| 通讯作者 | Zhai, qiwei(qwzhai@sibs.ac.cn) |
| 英文摘要 | Axon degeneration is a common hallmark of many neurodegenerative diseases, and the underlying mechanism remains largely unknown. lysosomes are involved in some neurodegenerative diseases, including alzheimer's disease and parkinson's disease. whether lysosomes are involved in axon degeneration is yet to be elucidated. in this study, we found only about 10% lysosomes remained in axons of cultured superior cervical ganglia (scgs) after transection for 4 h when stained with lysotracker. furthermore, we found that lysosomal disruption occurred earlier than morphological changes and loss of mitochondrial membrane potential. in addition. the well-known axon-protective protein wlds delayed injury-induced axon degeneration from both morphological changes and lysosomal disruption. lysosomal inhibitors including chloroquine and ammonium chloride induced axon degeneration in cultured scgs, and wld(s) also slowed down the axon degeneration induced by lysosomal inhibitors. all these data suggest that lysosomal disruption is an early marker of axon degeneration, and inhibition of lysosome induces axon degeneration in a wld(s)-protectable way. thus, maintenance of normal lysosomal function might be an important approach to delay axon degeneration in neurodegenerative diseases. (c) 2010 elsevier ltd. all rights reserved. |
| WOS关键词 | UBIQUITIN-PROTEASOME SYSTEM ; WALLERIAN DEGENERATION ; CELL-DEATH ; MEMBRANE PERMEABILIZATION ; CULTURED NEURONS ; IN-VIVO ; DISEASE ; NEURODEGENERATION ; TRANSPORT ; PROTEIN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| WOS类目 | Biochemistry & Molecular Biology ; Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000275949000020 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2411439 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhai, Qiwei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China 3.Zhejiang Sci Tech Univ, Sch Life Sci, Xinyuan Inst Med & Biotechnol, Hangzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Jin,Yan, Tingting,Feng, Yan,et al. Involvement of lysosomes in the early stages of axon degeneration[J]. Neurochemistry international,2010,56(3):516-521. |
| APA | Zheng, Jin,Yan, Tingting,Feng, Yan,&Zhai, Qiwei.(2010).Involvement of lysosomes in the early stages of axon degeneration.Neurochemistry international,56(3),516-521. |
| MLA | Zheng, Jin,et al."Involvement of lysosomes in the early stages of axon degeneration".Neurochemistry international 56.3(2010):516-521. |
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来源：中国科学院大学
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