High doses of alpha-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing th17 response
文献类型：期刊论文
| 作者 | Qian, Gaochao2; Qin, Xia2; Zang, Ying Qin3; Ge, Baoxue1; Guo, Taylor B.1; Wan, Bing1; Fang, Lei1; Zhang, Jingwu Z.1 |
| 刊名 | Cell research
 |
| 出版日期 | 2010-04-01 |
| 卷号 | 20期号:4页码:480-491 |
| 关键词 | Alpha-gc Experimental autoimmune encephalomyelitis Il-17 |
| ISSN号 | 1001-0602 |
| DOI | 10.1038/cr.2010.6 |
| 通讯作者 | Zhang, jingwu z.(jwzang@sibs.ac.cn) |
| 英文摘要 | Alpha-galactosylceramide (alpha-gc) is widely known to activate invariant natural killer t (inkt) cells to suppress myelin antigen-specific th1 responses, protecting susceptible mice against experimental autoimmune encephalomyelitis (eae). here, we demonstrate an unexpected finding that high doses of alpha-gc exacerbated, rather than ameliorated, eae. similar results were observed when mog(35-55)-specific t cells treated with high-dose alpha-gc were transferred into naive syngeneic recipient mice. further study showed that high doses of alpha-gc directly enhance the th17 and th1 response by activation of cd4(+)cd44(+) memory t cells through phosphorylation of stat3 and activation of nf-kappa b. unlike the activation of inkt cells by low doses of alpha-gc, high doses of alpha-gc directly interacted with cd1d expressed on t cells and activated th17 and th1 cells. furthermore, antigen-presenting cells (apcs) predominantly express cd1d1, whereas the majority of cd4(+) t cells express cd1d2. knockdown of cd1d1 or cd1d2 gene expression by rnai interfered with the activation of inkt or th17/th1 cells, respectively. therefore, alpha-gc treatment could improve or worsen eae by engaging either apcs or th17/th1 cells depending on the dose used. |
| WOS关键词 | KILLER T-CELLS ; ANTIGEN-PRESENTING MOLECULES ; INVARIANT NKT CELLS ; AIRWAY HYPERREACTIVITY ; INDUCED ARTHRITIS ; CD1 MOLECULES ; PRODUCE IL-17 ; CUTTING EDGE ; MOUSE CD1 ; ACTIVATION |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000276838100011 |
| 出版者 | INST BIOCHEMISTRY & CELL BIOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2411441 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Jingwu Z. |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai 200025, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qian, Gaochao,Qin, Xia,Zang, Ying Qin,et al. High doses of alpha-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing th17 response[J]. Cell research,2010,20(4):480-491. |
| APA | Qian, Gaochao.,Qin, Xia.,Zang, Ying Qin.,Ge, Baoxue.,Guo, Taylor B..,...&Zhang, Jingwu Z..(2010).High doses of alpha-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing th17 response.Cell research,20(4),480-491. |
| MLA | Qian, Gaochao,et al."High doses of alpha-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing th17 response".Cell research 20.4(2010):480-491. |
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来源：中国科学院大学
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