Induction of balance and breadth in the immune response is beneficial for the control of sivmac239 replication in rhesus monkeys
文献类型：期刊论文
| 作者 | Sun, Caijun1,2; Zhang, Lei1; Zhang, Maochao1; Liu, Yichu1; Zhong, Miao1,2; Ma, Xin1; Chen, Ling1,3 |
| 刊名 | Journal of infection
 |
| 出版日期 | 2010-05-01 |
| 卷号 | 60期号:5页码:371-381 |
| 关键词 | Hiv vaccine Immune balance Immune breadth Protection Sivmac239 |
| ISSN号 | 0163-4453 |
| DOI | 10.1016/j.jinf.2010.03.005 |
| 通讯作者 | Chen, ling(sun_caijun@gibh.ac.cn) |
| 英文摘要 | Objectives: the aim of this study was to induce cellular and humoral responses with enhanced breadth and more balanced magnitude as a possible approach for an effective hiv vaccine. methods: all nine of the sivmac239 genes (gag, pol, env, nef, vif, vpx, vpr, rev and tat) were optimized for mammalian expression, synthesized and cloned into recombinant adenovirus type 5 (ad5). these vectors were used as a vaccine regimen, and the immunogenicity and immune protection of this regimen was assessed in murine and macaques. results: a vaccine regimen including all nine genes of the sivmac239 virus was developed, and it was demonstrated that in contrast to single antigen vaccination, the total siv antigen regimen more effectively elicited the balanced and broad immune responses in murine and macaques. moreover, the responses afforded effective immune control against infection and replication of the highly pathogenic sivmac239. conclusions: induction of balance and breadth in the immune response is beneficial in controlling sivmac239 replication in rhesus monkeys. this study provides insight for the future development of an effective hiv vaccine. (c) 2010 the british infection society. published by elsevier ltd. all rights reserved. |
| WOS关键词 | SIMIAN IMMUNODEFICIENCY VIRUS ; CD4(+) T-CELLS ; HIV-1 VACCINE ; ANTIGENIC-COMPETITION ; DISEASE PROGRESSION ; DNA VACCINATION ; CHRONIC PHASE ; AIDS VACCINE ; ANIMAL-MODEL ; MACAQUES |
| WOS研究方向 | Infectious Diseases |
| WOS类目 | Infectious Diseases |
| 语种 | 英语 |
| WOS记录号 | WOS:000277203300009 |
| 出版者 | W B SAUNDERS CO LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2411886 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Ling |
| 作者单位 | 1.Chinese Acad Sci, GIBH, Guangzhou 510530, Guangdong, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.USTC, Coll Life Sci, Hefei 230027, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Caijun,Zhang, Lei,Zhang, Maochao,et al. Induction of balance and breadth in the immune response is beneficial for the control of sivmac239 replication in rhesus monkeys[J]. Journal of infection,2010,60(5):371-381. |
| APA | Sun, Caijun.,Zhang, Lei.,Zhang, Maochao.,Liu, Yichu.,Zhong, Miao.,...&Chen, Ling.(2010).Induction of balance and breadth in the immune response is beneficial for the control of sivmac239 replication in rhesus monkeys.Journal of infection,60(5),371-381. |
| MLA | Sun, Caijun,et al."Induction of balance and breadth in the immune response is beneficial for the control of sivmac239 replication in rhesus monkeys".Journal of infection 60.5(2010):371-381. |
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来源：中国科学院大学
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