Decreased serum levels of thioredoxin in patients with coronary artery disease plus hyperhomocysteinemia is strongly associated with the disease severity
文献类型：期刊论文
| 作者 | Wu, Yunfei1; Yang, Lijuan2; Zhong, Liangwei1 |
| 刊名 | Atherosclerosis
 |
| 出版日期 | 2010-09-01 |
| 卷号 | 212期号:1页码:351-355 |
| 关键词 | Coronary artery disease Homocysteine Thioredoxin Thioredoxin reductase Human serum |
| ISSN号 | 0021-9150 |
| DOI | 10.1016/j.atherosclerosis.2010.06.002 |
| 通讯作者 | Zhong, liangwei(liazho@gucas.ac.cn) |
| 英文摘要 | Objective: elevation of homocysteine and thioredoxin (trx) levels was found in some patients with coronary artery diseases (cad). however, their correlations with cad were not clear. dysfunction of thioredoxin/thioredoxin reductase (trxr) may cause oxidative stress that is common to cad. we seek to determine the association among homocysteine, trx/trxr and cad. methods: serum samples were collected from 150 cad patients under statin treatment and 122 non-cad controls. risk factors for atherosclerosis including homocysteine, lipids and glucose levels were analyzed. trx/trxr activities and protein levels were determined using super-insulin assay and western blot, respectively. one-way anova, tukey's post hoc test and spearman's rank correlation coefficient were used for statistical analysis. cad severity was evaluated by angiographic gensini score. results: compared with non-cad group, cad group had significantly increased trxr activity (p < 0.05) and homocysteine levels (p < 0.01), but not trxactivity. after further dividing cad group using homocysteine below 15 mu m asreference, trx activity decreased significantly in cad group with high homocysteine, and was inversely associated with homocysteine levels (r = -0.199, p < 0.05) that was, however, weakly positively associated with trxr activity. neither lipids nor glucose significantly affected trx/trxr activity. association of cad severity with low trx plus high homocysteine was strong (r = -0.458, p < 0.001), but with high homocysteine alone was rather weak (r = 0.125, p = 0.225). conclusion: in cad patients, high homocysteine levels may cause low trx activity, which is closely correlated to the extent and severity of cad. (c) 2010 elsevier ireland ltd. all rights reserved. |
| WOS关键词 | OXIDATIVE STRESS ; UP-REGULATION ; REDUCTASE ; HOMOCYSTEINE ; GLUTATHIONE ; SYSTEMS ; GLUTAREDOXIN ; ACTIVATION ; MECHANISMS ; SECRETION |
| WOS研究方向 | Cardiovascular System & Cardiology |
| WOS类目 | Peripheral Vascular Disease |
| 语种 | 英语 |
| WOS记录号 | WOS:000281459900057 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2411887 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhong, Liangwei |
| 作者单位 | 1.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yunfei,Yang, Lijuan,Zhong, Liangwei. Decreased serum levels of thioredoxin in patients with coronary artery disease plus hyperhomocysteinemia is strongly associated with the disease severity[J]. Atherosclerosis,2010,212(1):351-355. |
| APA | Wu, Yunfei,Yang, Lijuan,&Zhong, Liangwei.(2010).Decreased serum levels of thioredoxin in patients with coronary artery disease plus hyperhomocysteinemia is strongly associated with the disease severity.Atherosclerosis,212(1),351-355. |
| MLA | Wu, Yunfei,et al."Decreased serum levels of thioredoxin in patients with coronary artery disease plus hyperhomocysteinemia is strongly associated with the disease severity".Atherosclerosis 212.1(2010):351-355. |
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来源：中国科学院大学
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