Role of secretory protease inhibitor spink3 in mouse uterus during early pregnancy
文献类型：期刊论文
| 作者 | Chen, Wen1,2; Han, Bing-Chen1; Wang, Rong-Chun1; Xiong, Gao-Feng1; Peng, Jing-Pian1 |
| 刊名 | Cell and tissue research
 |
| 出版日期 | 2010-09-01 |
| 卷号 | 341期号:3页码:441-451 |
| 关键词 | Spink3 Uterus Implantation Decidualization Progesterone Mouse (kunming white) |
| ISSN号 | 0302-766X |
| DOI | 10.1007/s00441-010-1013-5 |
| 通讯作者 | Peng, jing-pian(pengjp@ioz.ac.cn) |
| 英文摘要 | Successful embryo implantation depends on intricate epithelial-stromal cross-talk. however, molecular modulators involved in this cellular communication remain poorly elucidated. using multiple approaches, we have investigated the spatiotemporal expression and regulation of serine protease inhibitor kazal type 3 (spink3) in mouse uterus during the estrous cycle and early pregnancy. in cycling mice, both spink3 mrna and protein are only expressed during proestrus. in the pregnant mouse, the expression levels of both spink3 mrna and protein increase on days 5-8 and then decline. spink3 mrna is expressed exclusively in the uterine glandular epithelium, whereas spink3 protein is localized on the surface of both luminal and glandular epithelium and in the decidua. moreover, spink3 in the decidua has been observed in the primary decidual zone on day 6 and the secondary decidual zone on days 7-8; this is tightly associated with the progression of decidualization. spink3 has also been found in decidual cells of the artificially decidualized uterine horn but not control horn, whereas spink3 mrna localizes in the glands of both horns. the expression of endometrial spink3 is not regulated by the blastocyst according to its expression pattern during pseudopregnancy and delayed implantation but is induced by progesterone and further augmented by a combination of progesterone and estrogen in ovariectomized mice. thus, uterine-gland-derived spink3, as a new paracrine modulator, might play an important role in embryo implantation through its influence on stromal decidualization in mice. |
| WOS关键词 | STROMAL CELL DECIDUALIZATION ; PANCREATIC ACINAR-CELLS ; TRYPSIN-INHIBITOR ; EMBRYO IMPLANTATION ; GENE-EXPRESSION ; MAMMARY-GLAND ; INDIAN HEDGEHOG ; SPERM-BINDING ; ESTROUS-CYCLE ; PROGESTERONE |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000281670800010 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2411905 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Peng, Jing-Pian |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100010, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Wen,Han, Bing-Chen,Wang, Rong-Chun,et al. Role of secretory protease inhibitor spink3 in mouse uterus during early pregnancy[J]. Cell and tissue research,2010,341(3):441-451. |
| APA | Chen, Wen,Han, Bing-Chen,Wang, Rong-Chun,Xiong, Gao-Feng,&Peng, Jing-Pian.(2010).Role of secretory protease inhibitor spink3 in mouse uterus during early pregnancy.Cell and tissue research,341(3),441-451. |
| MLA | Chen, Wen,et al."Role of secretory protease inhibitor spink3 in mouse uterus during early pregnancy".Cell and tissue research 341.3(2010):441-451. |
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来源：中国科学院大学
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