Blos1, a putative bloc-1 subunit, interacts with snx1 and modulates root growth in arabidopsis
文献类型：期刊论文
| 作者 | Cui, Yanyan2,3; Li, Xugang1; Chen, Qingguo2,3; He, Xin3; Yang, Qing2,3; Zhang, Aili2,3; Yu, Xin1; Chen, Hao2,3; Liu, Naiyou3; Xie, Qi3 |
| 刊名 | Journal of cell science
 |
| 出版日期 | 2010-11-01 |
| 卷号 | 123期号:21页码:3727-3733 |
| 关键词 | Biogenesis of lysosome-related organelles complex 1 (bloc-1) Sorting nexin 1 (snx1) Auxin efflux transporter Root growth Endosomal transport Vacuole |
| ISSN号 | 0021-9533 |
| DOI | 10.1242/jcs.069732 |
| 通讯作者 | Palme, klaus(klaus.palme@biologie.uni-freiburg.de) |
| 英文摘要 | Internalization and sorting of macromolecules are inherent properties of all eukaryotic cells that are achieved by vesicle trafficking. however, this process is relatively less understood in plants. an eight-subunit protein complex, bloc-1, which is involved in endosomal transport from the endosomes to the lysosomes, has been identified in both human and mice. in this study, two homologous subunits of this complex, blos1 (or atgcn5l1) and blos2, have been characterized in arabidopsis. both blos1 and blos2 interacted with snx1 on the sorting endosomes. inducible rnai lines with reduced levels of blos1 had longer primary roots and more lateral roots. consistently, pin1 and pin2 were increased in blos1 rnai lines, implicating an impaired transport from the endosomes to the vacuoles. these results suggest that a putative bloc-1 complex in arabidopsis might mediate the vacuolar degradative transport through direct interaction with snx1 to regulate the homeostasis of pin1 and pin2, which is important for plant growth and development. |
| WOS关键词 | LYSOSOME-RELATED ORGANELLES ; AUXIN EFFLUX CARRIER ; GNOM ARF-GEF ; ENDOCYTIC PATHWAY ; SORTING NEXIN-1 ; EARLY ENDOSOMES ; PROTEIN ; TRANSPORT ; CELLS ; TRAFFICKING |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000283796700013 |
| 出版者 | COMPANY OF BIOLOGISTS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2411965 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Palme, Klaus |
| 作者单位 | 1.Univ Freiburg, Inst Biol 2, D-79104 Freiburg, Germany 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Yanyan,Li, Xugang,Chen, Qingguo,et al. Blos1, a putative bloc-1 subunit, interacts with snx1 and modulates root growth in arabidopsis[J]. Journal of cell science,2010,123(21):3727-3733. |
| APA | Cui, Yanyan.,Li, Xugang.,Chen, Qingguo.,He, Xin.,Yang, Qing.,...&Li, Wei.(2010).Blos1, a putative bloc-1 subunit, interacts with snx1 and modulates root growth in arabidopsis.Journal of cell science,123(21),3727-3733. |
| MLA | Cui, Yanyan,et al."Blos1, a putative bloc-1 subunit, interacts with snx1 and modulates root growth in arabidopsis".Journal of cell science 123.21(2010):3727-3733. |
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来源：中国科学院大学
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