Radiolabeling rgd peptide and preliminary biodistribution evaluation in mice bearing s180 tumors
文献类型：期刊论文
| 作者 | Ma, Yufei2; Yu, Junfeng1; Han, Yanjiang2; Shen, Hua; Li, Zheng2; Zhou, Wei; Yin, Duanzhi |
| 刊名 | Nuclear medicine communications
 |
| 出版日期 | 2010-02-01 |
| 卷号 | 31期号:2页码:147-151 |
| 关键词 | Arginine-glycine-aspartic acid Biodistribution Radiolabeling Rhenium-188 |
| ISSN号 | 0143-3636 |
| DOI | 10.1097/mnm.0b013e3283334e48 |
| 通讯作者 | Yu, junfeng(yujf@sinap.ac.cn) |
| 英文摘要 | Objective to prepare the rhenium-188 ((188)re)-arginine-glycine-aspartic acid (rgd) peptide in a convenient manner and to evaluate its potential as an agent for alpha(v)beta(3) integrin receptor-positive tumors. methods radiolabeled rgd was obtained by conjugating the his group at the end of peptide with fac-[(188)re(h(2)o)(3)(co)(3)](+). chelating efficiency of fac-[(188)re(h(2)o)(3)(co)(3)](+) and radiolabeling efficiency of radiolabeled peptide were measured by thin-layer chromatography and high-performance liquid chromatography. in-vitro stability of the radio-complex was determined in phosphate-buffered saline (0.05 mol/l, ph 74), new-born calf serum, his or cys solution at 37 degrees c or room temperature and analyzed by thin-layer chromatography. a biodistribution study was carried out in mice bearing s180 tumors. results (188)re-rgd was obtained with a more than 95% of radiolabeling efficiency, and showed high stability in phosphate-buffered saline, new-born calf serum, his and cys solution. furthermore, this radio-complex was cleared rapidly from the blood and showed specific tumor uptake in mice bearing s180 tumors. conclusion (188)re-rgd was prepared by a simple method. preliminary biodistribution results showed its potential as an agent for cancer therapy and encouraged further investigation. nucl med commun 31:147-151 (c) 2010 wolters kluwer health vertical bar lippincott williams & wilkins. |
| WOS关键词 | BIFUNCTIONAL LIGAND ; BIOMOLECULES ; ANGIOGENESIS ; INTEGRINS |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000273466500010 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2411974 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu, Junfeng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Ctr Radiopharmaceut Res, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Yufei,Yu, Junfeng,Han, Yanjiang,et al. Radiolabeling rgd peptide and preliminary biodistribution evaluation in mice bearing s180 tumors[J]. Nuclear medicine communications,2010,31(2):147-151. |
| APA | Ma, Yufei.,Yu, Junfeng.,Han, Yanjiang.,Shen, Hua.,Li, Zheng.,...&Yin, Duanzhi.(2010).Radiolabeling rgd peptide and preliminary biodistribution evaluation in mice bearing s180 tumors.Nuclear medicine communications,31(2),147-151. |
| MLA | Ma, Yufei,et al."Radiolabeling rgd peptide and preliminary biodistribution evaluation in mice bearing s180 tumors".Nuclear medicine communications 31.2(2010):147-151. |
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来源：中国科学院大学
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