Pml/rar alpha targets promoter regions containing pu.1 consensus and rare half sites in acute promyelocytic leukemia
文献类型：期刊论文
| 作者 | Wang, Kankan1; Wang, Ping1; Shi, Jiantao2,3; Zhu, Xuehua2,3; He, Miaomiao1; Jia, Xiaohong1; Yang, Xianwen1; Qiu, Fei1; Jin, Wen1; Qian, Maoxiang2,3 |
| 刊名 | Cancer cell
 |
| 出版日期 | 2010-02-17 |
| 卷号 | 17期号:2页码:186-197 |
| ISSN号 | 1535-6108 |
| DOI | 10.1016/j.ccr.2009.12.045 |
| 通讯作者 | Zhang, ji(jizhang@sibs.ac.cn) |
| 英文摘要 | Pml/rar alpha is of crucial importance in acute promyelocytic leukemia (apl) both pathologically and therapeutically. using a genome-wide approach, we identified in vivo pml/rar alpha binding sites in a pml/rar alpha-inducible cell model. of the 2979 targeted regions, >62% contained canonical pu.1 motifs and >84% of these pu.1 motifs coexisted with one or more rare half (rareh) sites in nearby regions. promoters with such pu.1-rareh binding sites were transactivated by pu.1. pu.1-mediated transactivation was repressed by pml/rar alpha and restored by the addition of all-trans retinoic acid (atra). genes containing such promoters were significantly represented by genes transcriptionally suppressed in apl and/or reactivated upon treatment with atra. thus, selective targeting of pu.1-regulated genes by pml/rar alpha is a critical mechanism for the pathogenesis of apl. |
| WOS关键词 | ACUTE MYELOID-LEUKEMIA ; FUSION PROTEIN ; HEMATOPOIETIC PROGENITORS ; HUMAN GENOME ; PML ; DIFFERENTIATION ; EXPRESSION ; RECEPTOR ; CELLS ; RXR |
| WOS研究方向 | Oncology ; Cell Biology |
| WOS类目 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000274766800010 |
| 出版者 | CELL PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2412379 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Ji |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Sinofrench Res Ctr Life Sci & Genom, State Key Lab Med Genom,Rui Jin Hosp, Shanghai 200025, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shanghai 200025, Peoples R China 4.Princess Margaret Hosp, Ontario Canc Inst, Univ Hlth Network, Toronto, ON M5G 2M9, Canada |
| 推荐引用方式 GB/T 7714 | Wang, Kankan,Wang, Ping,Shi, Jiantao,et al. Pml/rar alpha targets promoter regions containing pu.1 consensus and rare half sites in acute promyelocytic leukemia[J]. Cancer cell,2010,17(2):186-197. |
| APA | Wang, Kankan.,Wang, Ping.,Shi, Jiantao.,Zhu, Xuehua.,He, Miaomiao.,...&Zhang, Ji.(2010).Pml/rar alpha targets promoter regions containing pu.1 consensus and rare half sites in acute promyelocytic leukemia.Cancer cell,17(2),186-197. |
| MLA | Wang, Kankan,et al."Pml/rar alpha targets promoter regions containing pu.1 consensus and rare half sites in acute promyelocytic leukemia".Cancer cell 17.2(2010):186-197. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。