Wld(s), nmnats and axon degeneration-progress in the past two decades
文献类型：期刊论文
| 作者 | Feng, Yan1,2; Yan, Tingting1,2; He, Zhigang3,4; Zhai, Qiwei1,2 |
| 刊名 | Protein & cell
 |
| 出版日期 | 2010-03-01 |
| 卷号 | 1期号:3页码:237-245 |
| 关键词 | Axon degeneration Wallerian degeneration Wld(s) Nad Neurodegenerative diseases |
| ISSN号 | 1674-800X |
| DOI | 10.1007/s13238-010-0021-2 |
| 通讯作者 | Zhai, qiwei(qwzhai@sibs.ac.cn) |
| 英文摘要 | A chimeric protein called wallerian degeneration slow (wld(s)) was first discovered in a spontaneous mutant strain of mice that exhibited delayed wallerian degeneration. this provides a useful tool in elucidating the mechanisms of axon degeneration. over-expression of wld(s) attenuates the axon degeneration that is associated with several neurodegenerative disease models, suggesting a new logic for developing a potential protective strategy. at molecular level, although wld(s) is a fusion protein, the nicotinamide mononucleotide adenylyl transferase 1 (nmnat1) is required and sufficient for the protective effects of wld(s), indicating a critical role of nad biosynthesis and perhaps energy metabolism in axon degeneration. these findings challenge the proposed model in which axon degeneration is operated by an active programmed process and thus may have important implication in understanding the mechanisms of neurodegeneration. in this review, we will summarize these recent findings and discuss their relevance to the mechanisms of axon degeneration. |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000208510600006 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2412466 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhai, Qiwei |
| 作者单位 | 1.Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China 3.Harvard Univ, Sch Med, Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA 4.Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA |
| 推荐引用方式 GB/T 7714 | Feng, Yan,Yan, Tingting,He, Zhigang,et al. Wld(s), nmnats and axon degeneration-progress in the past two decades[J]. Protein & cell,2010,1(3):237-245. |
| APA | Feng, Yan,Yan, Tingting,He, Zhigang,&Zhai, Qiwei.(2010).Wld(s), nmnats and axon degeneration-progress in the past two decades.Protein & cell,1(3),237-245. |
| MLA | Feng, Yan,et al."Wld(s), nmnats and axon degeneration-progress in the past two decades".Protein & cell 1.3(2010):237-245. |
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来源：中国科学院大学
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