Facile synthesis of glycopolypeptides by combination of ring-opening polymerization of an alkyne-substituted n-carboxyanhydride and click "glycosylation"
文献类型：期刊论文
| 作者 | Xiao, Chunsheng1,2; Zhao, Changwen1,2; He, Pan1,2; Tang, Zhaohui1; Chen, Xuesi1; Jing, Xiabin1 |
| 刊名 | Macromolecular rapid communications
 |
| 出版日期 | 2010-06-02 |
| 卷号 | 31期号:11页码:991-997 |
| ISSN号 | 1022-1336 |
| 关键词 | Alkynes Click chemistry Glycopolypeptides N-carboxyanhydride (nca) Polypeptides |
| DOI | 10.1002/marc.200900821 |
| 通讯作者 | Chen, xuesi(xschen@ciac.jl.cn) |
| 英文摘要 | Synthetic glycopolypeptides have attracted much interest for application in biomedical field as they are structural mimics to the natural glycopeptides or glycoproteins. however, the synthesis methods toward glycopolypeptides are still few or less efficient. herein, we present a facile route to preparation of glycopolypeptides with highly effective "glycosylation" by click postpolymerization modification. first, an alkyne-substituted n-carboxyanhydride (nca) monomer was synthesized and subsequently polymerized to afford the polypeptide with "clickable" alkyne pendants. the alkyne-functionalized polypeptide was then "glycosylated" by click reaction of different sugar azides to the alkyne pendants with high efficiency. all the obtained glycopolypeptides were soluble and preferred a-helix conformation in water. primary studies on the obtained glycopolypeptides binding with con a lectin were assessed by turbidimetric assay. the more quantitive studies of the interactions between lectin proteins and the synthetic glycopolypeptides, and the application of these materials as the multivalent ligands are in progress. |
| WOS关键词 | LIVING RADICAL POLYMERIZATION ; BLOCK-COPOLYMERS ; ESCHERICHIA-COLI ; POLYPEPTIDE BACKBONE ; TRIBLOCK COPOLYMERS ; CIRCULAR-DICHROISM ; CHOLERA-TOXIN ; GLYCOPOLYMERS ; ACID ; GLYCOPEPTIDE |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| 出版者 | WILEY-BLACKWELL |
| WOS记录号 | WOS:000279099300005 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2412612 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Xuesi |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Chunsheng,Zhao, Changwen,He, Pan,et al. Facile synthesis of glycopolypeptides by combination of ring-opening polymerization of an alkyne-substituted n-carboxyanhydride and click "glycosylation"[J]. Macromolecular rapid communications,2010,31(11):991-997. |
| APA | Xiao, Chunsheng,Zhao, Changwen,He, Pan,Tang, Zhaohui,Chen, Xuesi,&Jing, Xiabin.(2010).Facile synthesis of glycopolypeptides by combination of ring-opening polymerization of an alkyne-substituted n-carboxyanhydride and click "glycosylation".Macromolecular rapid communications,31(11),991-997. |
| MLA | Xiao, Chunsheng,et al."Facile synthesis of glycopolypeptides by combination of ring-opening polymerization of an alkyne-substituted n-carboxyanhydride and click "glycosylation"".Macromolecular rapid communications 31.11(2010):991-997. |
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来源：中国科学院大学
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