Pore-like aggregates of tau protein induced by formaldehyde
文献类型：期刊论文
| 作者 | Naqvi, Sajjad Haider1,2; Wang Wei-Shan3; Miao Jun-Ye1,2; He Rong-Qiao1,2 |
| 刊名 | Progress in biochemistry and biophysics
 |
| 出版日期 | 2010-11-01 |
| 卷号 | 37期号:11页码:1195-1203 |
| 关键词 | Tau protein Formaldehyde Misfolding Pore-like aggregates Neurodegeneration Chronic impairment Sporadic alzheimer's diseases |
| ISSN号 | 1000-3282 |
| DOI | 10.3724/sp.j.1206.2010.00375 |
| 通讯作者 | He rong-qiao() |
| 英文摘要 | Though the hypothesis of "aspecific amyloid ion channels" has been proposed by lin, et at (university of california, santa barbara) to explain the mechanism of metabolic dysfunction and cell death during protein conformational diseases, the "pore-like" aggregates of misfolded neural tau have not been observed revulsants involved in the formation of "pore-like" aggregates have not been found yet according to the hypothesis "chronic impairment resulted from abnormally-increased endogenous formaldehyde is one of the important risk factors related to sporadic senile dementia", formaldehyde has been utilized to incubate with tau protein resulting in amyloid-like deposits with marked cytotoxicity under the experimental conditions, 0 5% formaldehyde-treated tau could form "pore-like" aggregates these results may deliver a novel approach to study the mechanism of cellular metabolic disturbance, even cell death, which is induced by formaldehyde-treated neural tau |
| WOS关键词 | DISEASE ; NEURODEGENERATION ; CONFORMATION ; TUBULIN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000284722900005 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2412639 |
| 专题 | 中国科学院大学 |
| 通讯作者 | He Rong-Qiao |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Beijing Hosp Elderly, Beijing 100095, Peoples R China |
| 推荐引用方式 GB/T 7714 | Naqvi, Sajjad Haider,Wang Wei-Shan,Miao Jun-Ye,et al. Pore-like aggregates of tau protein induced by formaldehyde[J]. Progress in biochemistry and biophysics,2010,37(11):1195-1203. |
| APA | Naqvi, Sajjad Haider,Wang Wei-Shan,Miao Jun-Ye,&He Rong-Qiao.(2010).Pore-like aggregates of tau protein induced by formaldehyde.Progress in biochemistry and biophysics,37(11),1195-1203. |
| MLA | Naqvi, Sajjad Haider,et al."Pore-like aggregates of tau protein induced by formaldehyde".Progress in biochemistry and biophysics 37.11(2010):1195-1203. |
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来源：中国科学院大学
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