Pharmacokinetics of a novel nifedipine and ph-sensitive n-succinyl chitosan/alginate hydrogel bead in rabbits
文献类型：期刊论文
| 作者 | Zhu, Xu-Jiang1,2,3; Yuan, Wei2; Li, Ping4; Liu, Xia1; He, Jun-Quan2 |
| 刊名 | Drug development and industrial pharmacy
 |
| 出版日期 | 2010-12-10 |
| 卷号 | 36期号:12页码:1463-1468 |
| 关键词 | Hplc-uv Hydrogel Nifedipine N-succinyl chitosan Pharmacokinetics Ph sensitivity Rabbit serum |
| ISSN号 | 0363-9045 |
| DOI | 10.3109/03639045.2010.488644 |
| 通讯作者 | Liu, xia(gsliu.xia@163.com) |
| 英文摘要 | Context: a novel n-succinyl chitosan/alginate hydrogel bead was prepared by the ionic gelation method for controlled delivery of nifedipine (nf). objective: the delivery behavior of nf from the hydrogel bead was studied in rabbit body. materials and methods: nitrendipine was used as the internal standard and the concentration of nf in serum was determined by reversed-phase high-performance liquid chromatography. results: the assay was linear from 5 to 755 ng/ml. the limit of quantitation for nf was 5 ng/ml in serum, and the recovery was greater than 90%. the method was used to determine the concentration-time profiles of nf in the serum. the pharmacokinetic parameters were calculated by drug and statistics (ver 1.0) program. the mean cmax was 320.2 +/- 71.3 mu g/l, the mean tmax was 3.2 +/- 0.5 hours, the mean t1/2 was 6.60 +/- 2.17 hours, the mean auc0-24 was 2.03 +/- 0.25 mg h/l, the mean auc0-infinity was 2.50 +/- 0.36 mg h/l, the mean mrt0-24 was 8.57 +/- 0.19 hours, and the mean mrt0-infinity was 15.2 +/- 1.8 hours. discussion and conclusion: the pharmacokinetic characteristics were found by a two-compartment model following the oral administration of nf-loaded n-succinyl chitosan/alginate hydrogel beads in rabbits. |
| WOS关键词 | LIQUID-CHROMATOGRAPHIC DETERMINATION ; DRUG-RELEASE ; DELIVERY ; PLASMA |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000283874400009 |
| 出版者 | INFORMA HEALTHCARE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2412644 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Xia |
| 作者单位 | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 2.Gansu Inst Drug Control, Lanzhou, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 4.Chinese Acad Sci, Hosp 2, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Xu-Jiang,Yuan, Wei,Li, Ping,et al. Pharmacokinetics of a novel nifedipine and ph-sensitive n-succinyl chitosan/alginate hydrogel bead in rabbits[J]. Drug development and industrial pharmacy,2010,36(12):1463-1468. |
| APA | Zhu, Xu-Jiang,Yuan, Wei,Li, Ping,Liu, Xia,&He, Jun-Quan.(2010).Pharmacokinetics of a novel nifedipine and ph-sensitive n-succinyl chitosan/alginate hydrogel bead in rabbits.Drug development and industrial pharmacy,36(12),1463-1468. |
| MLA | Zhu, Xu-Jiang,et al."Pharmacokinetics of a novel nifedipine and ph-sensitive n-succinyl chitosan/alginate hydrogel bead in rabbits".Drug development and industrial pharmacy 36.12(2010):1463-1468. |
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来源：中国科学院大学
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