Ph-responsive silica nanoparticles for controllable o-1(2) generation
文献类型：期刊论文
| 作者 | Li, Zhaobo1,2; Wang, Jianguang1,2; Chen, Jingrong1; Lei, Wanhua1; Wang, Xuesong1; Zhang, Baowen1 |
| 刊名 | Nanotechnology
 |
| 出版日期 | 2010-03-19 |
| 卷号 | 21期号:11页码:6 |
| ISSN号 | 0957-4484 |
| DOI | 10.1088/0957-4484/21/11/115102 |
| 通讯作者 | Wang, xuesong(xswang@mail.ipc.ac.cn) |
| 英文摘要 | Ph-responsive o-1(2) photosensitizing systems may serve as selective photodynamic therapy (pdt) agents by targeting the acidic interstitial fluid of many kinds of tumors. in this work, we present a ph-responsive nanoparticle-based platform for controllable o-1(2) generation, in which a hydrophobic o-1(2) photosensitizer (meso-tetraphenylporphyrin, tpp) and a ph indicator (bromocresol purple, bcp, or bromothymol blue, btb) are simultaneously encapsulated in organically modified silica nanoparticles (osnp). in basic conditions, the ph indicator absorbs light competitively and thus restricts sensitizer excitation. in acidic solution, the blue shifted absorption of the ph indicator allows the efficient excitation of the sensitizer. the ph indicator serves as an 'inner filter' to modulate effectively the excitation of the sensitizer and thus the o-1(2) generation efficiency. |
| WOS关键词 | ORGANICALLY MODIFIED SILICA ; 2-PHOTON PHOTODYNAMIC THERAPY ; ANTICANCER DRUGS ; ENERGY-TRANSFER ; SINGLET OXYGEN ; BODIPY DYES ; IN-VITRO ; DELIVERY ; TETRAPHENYLPORPHYRIN ; PHOTOSENSITIZERS |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000274936700002 |
| 出版者 | IOP PUBLISHING LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2412660 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Xuesong |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhaobo,Wang, Jianguang,Chen, Jingrong,et al. Ph-responsive silica nanoparticles for controllable o-1(2) generation[J]. Nanotechnology,2010,21(11):6. |
| APA | Li, Zhaobo,Wang, Jianguang,Chen, Jingrong,Lei, Wanhua,Wang, Xuesong,&Zhang, Baowen.(2010).Ph-responsive silica nanoparticles for controllable o-1(2) generation.Nanotechnology,21(11),6. |
| MLA | Li, Zhaobo,et al."Ph-responsive silica nanoparticles for controllable o-1(2) generation".Nanotechnology 21.11(2010):6. |
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来源：中国科学院大学
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