Design, synthesis and discovery of 5-hydroxyaurone derivatives as growth inhibitors against huvec and some cancer cell lines
文献类型：期刊论文
| 作者 | Cheng, Huimin1,4; Zhang, Lianwen1,5; Liu, Yingxue1; Chen, Shaopeng1; Cheng, Hao1; Lu, Xin1; Zheng, Zhuxia1,5; Zhou, Guo-Chun1,2,3 |
| 刊名 | European journal of medicinal chemistry
 |
| 出版日期 | 2010-12-01 |
| 卷号 | 45期号:12页码:5950-5957 |
| 关键词 | 5-hydroxyaurone Anti-angiogenesis agent Conventional anticancer agent Cell migration Tube formation Cell invasion |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2010.09.061 |
| 通讯作者 | Zhou, guo-chun(allspringzhou@yahoo.com) |
| 英文摘要 | A series of 4'-substituted 5-hydroxyaurone derivatives were synthesized and their inhibitory activities against the proliferation of endothelial cells and two cancer cell lines were studied. some of these compounds functioned as potent inhibitors against the proliferation of endothelial cells and cancer cells but possessed much weaker cytotoxic activities against non-cancer cell line of ccc-hpf-1. it was demonstrated that two most active compounds 16 and 27 effectively inhibited in vitro endothelial cell motility and tube formation, which are basic properties of endothelial cells for angiogenesis. moreover, 16 and 27 also showed significant activities against in vitro cancer cell invasion, indicating that they have potential to inhibit cancer metastasis. these composite results suggest that 4'-substituted 5-hydroxyaurone is indeed a candidate structural scaffold for anticancer agent targeting activated endothelial cells and fast-proliferating cancer cells. (c) 2010 elsevier masson sas. all rights reserved. |
| WOS关键词 | TUMOR ANGIOGENESIS ; UVARIA-HAMILTONII ; ANTICANCER AGENTS ; P-GLYCOPROTEIN ; ANALOGS ; AURONES ; RESISTANCE ; FLAVONES ; PATHWAY |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal |
| 语种 | 英语 |
| WOS记录号 | WOS:000285485000048 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2412744 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou, Guo-Chun |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China 2.Nanjing Univ Technol, Coll Biotechnol & Pharmaceut Engn, Nanjing 210009, Peoples R China 3.Nanjing Univ Technol, Coll Pharmaceut Sci, Nanjing 210009, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 5.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Huimin,Zhang, Lianwen,Liu, Yingxue,et al. Design, synthesis and discovery of 5-hydroxyaurone derivatives as growth inhibitors against huvec and some cancer cell lines[J]. European journal of medicinal chemistry,2010,45(12):5950-5957. |
| APA | Cheng, Huimin.,Zhang, Lianwen.,Liu, Yingxue.,Chen, Shaopeng.,Cheng, Hao.,...&Zhou, Guo-Chun.(2010).Design, synthesis and discovery of 5-hydroxyaurone derivatives as growth inhibitors against huvec and some cancer cell lines.European journal of medicinal chemistry,45(12),5950-5957. |
| MLA | Cheng, Huimin,et al."Design, synthesis and discovery of 5-hydroxyaurone derivatives as growth inhibitors against huvec and some cancer cell lines".European journal of medicinal chemistry 45.12(2010):5950-5957. |
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来源：中国科学院大学
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